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1gcu

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[[Image:1gcu.jpg|left|200px]]
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{{Structure
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|PDB= 1gcu |SIZE=350|CAPTION= <scene name='initialview01'>1gcu</scene>, resolution 1.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1gcu", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Biliverdin_reductase Biliverdin reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.24 1.3.1.24] </span>
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{{STRUCTURE_1gcu| PDB=1gcu | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gcu OCA], [http://www.ebi.ac.uk/pdbsum/1gcu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gcu RCSB]</span>
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'''CRYSTAL STRUCTURE OF RAT BILIVERDIN REDUCTASE AT 1.4 A'''
'''CRYSTAL STRUCTURE OF RAT BILIVERDIN REDUCTASE AT 1.4 A'''
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[[Category: Park, S Y.]]
[[Category: Park, S Y.]]
[[Category: Shiro, Y.]]
[[Category: Shiro, Y.]]
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[[Category: biliverdin]]
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[[Category: Biliverdin]]
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[[Category: rossmann fold]]
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[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:25:32 2008''
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Revision as of 14:25, 2 May 2008

Image:1gcu.jpg

Template:STRUCTURE 1gcu

CRYSTAL STRUCTURE OF RAT BILIVERDIN REDUCTASE AT 1.4 A


Overview

Biliverdin reductase (BVR) is a soluble cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin using NADH or NADPH as electron donor. Bilirubin is a significant biological antioxidant, but it is also neurotoxic and the cause of kernicterus. In this study, we have determined the crystal structure of rat BVR at 1.4 A resolution. The structure contains two domains: an N-terminal domain characteristic of a dinucleotide binding fold (Rossmann fold) and a C-terminal domain that is predominantly an antiparallel six-stranded beta-sheet. Based on this structure, we propose modes of binding for NAD(P)H and biliverdin, and a possible mechanism for the enzyme.

About this Structure

1GCU is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of rat biliverdin reductase., Kikuchi A, Park SY, Miyatake H, Sun D, Sato M, Yoshida T, Shiro Y, Nat Struct Biol. 2001 Mar;8(3):221-5. PMID:11224565 Page seeded by OCA on Fri May 2 17:25:32 2008

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