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1gea
From Proteopedia
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[[Image:1gea.gif|left|200px]] | [[Image:1gea.gif|left|200px]] | ||
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'''RECEPTOR-BOUND CONFORMATION OF PACAP21''' | '''RECEPTOR-BOUND CONFORMATION OF PACAP21''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GEA is a [[Single protein]] structure | + | 1GEA is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEA OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Onda, H.]] | [[Category: Onda, H.]] | ||
[[Category: Shirakawa, M.]] | [[Category: Shirakawa, M.]] | ||
| - | [[Category: | + | [[Category: Beta coil]] |
| - | [[Category: | + | [[Category: Consecutive beta turn]] |
| - | [[Category: | + | [[Category: Helix]] |
| - | [[Category: | + | [[Category: Type-i beta turn]] |
| - | [[Category: | + | [[Category: Type-ii beta turn]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:27:57 2008'' | |
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Revision as of 14:27, 2 May 2008
RECEPTOR-BOUND CONFORMATION OF PACAP21
Overview
Many peptide hormones elicit a wide array of physiological effects by binding to G-protein coupled receptors. We have determined the conformation of pituitary adenylate cyclase activating polypeptide, PACAP(1--21)NH(2), bound to a PACAP-specific receptor by NMR spectroscopy. Residues 3--7 form a unique beta-coil structure that is preceded by an N-terminal extended tail. This beta-coil creates a patch of hydrophobic residues that is important for receptor binding. In contrast, the C-terminal region (residues 8--21) forms an alpha-helix, similar to that in the micelle-bound PACAP. Thus, the conformational difference between PACAP in the receptor-bound and the micelle-bound states is limited to the N-terminal seven residues. This observation is consistent with the two-step ligand transportation model in which PACAP first binds to the membrane nonspecifically and then diffuses two-dimensionally in search of its receptor; a conformational change at the N-terminal region then allows specific interactions between the ligand and the receptor.
About this Structure
1GEA is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Conformation of a peptide ligand bound to its G-protein coupled receptor., Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M, Nat Struct Biol. 2001 Feb;8(2):161-5. PMID:11175907 Page seeded by OCA on Fri May 2 17:27:57 2008
