Sandbox Reserved 429
From Proteopedia
(→=Overall Structure) |
(→=Overall Structure) |
||
| Line 33: | Line 33: | ||
==Quiz Question 1== | ==Quiz Question 1== | ||
| + | |||
| + | Question related to PBP evolution and developing resistance to ß-lactams, likely related to active site mutations. | ||
| + | Shows the <scene name='48/483886/Conserved_residues_of_pbp/2'>conserved residues of Penicillin Binding Protein</scene> from most conserved to most variable.{{Template:ColorKey_ConSurf}} | ||
| + | |||
| + | <Structure load='1a84' size='300' frame='true' align='right' caption='2jch, Insert caption here' scene='Insert optional scene name here' /> | ||
| + | <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | ||
<Structure load='1a84' size='300' frame='true' align='right' caption='2jch, Insert caption here' scene='Insert optional scene name here' /> | <Structure load='1a84' size='300' frame='true' align='right' caption='2jch, Insert caption here' scene='Insert optional scene name here' /> | ||
<br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | ||
Revision as of 20:16, 26 February 2016
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
Penicillin binding protein/lactivicin (inhibitor) (2jch)[1]
by Tyler Carpenter, Samuel Pierce, Hyunjoon Choi, Anton El Khoury and Tiankai Zhang
Student Projects for UMass Chemistry 423 Spring 2016
Introduction
|
Outline:
1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam.
2) Ligands, in particular . Also, how PBP binds lactivicin.
Sample green scene: Penicillin-binding protein has four ligands, one of which is
=Overall Structure
The secondary structures of PBP have certain affects on ligands Ligand has oxyanion hole to further binding potential. How does this help?
|
Binding Interactions
|
Additional Features
|
Quiz Question 1
Question related to PBP evolution and developing resistance to ß-lactams, likely related to active site mutations.
Shows the from most conserved to most variable.
|
|
See Also
Credits
Introduction - Anton El Khoury
Overall Structure - Tyler Carpenter
Drug Binding Site - name of team member
Additional Features - name of team member
Quiz Question 1 - Samuel Pierce
References
- ↑ Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ. Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. PMID:17676039 doi:10.1038/nchembio.2007.21
