Sandbox Reserved 429
From Proteopedia
(Difference between revisions)
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[[Student Projects for UMass Chemistry 423 Spring 2016]] | [[Student Projects for UMass Chemistry 423 Spring 2016]] | ||
| + | <StructureSection load='2jch' size='350' side='right' caption='caption for Molecular Playground (PDB entry [[2jch]])' scene=''> | ||
==Introduction== | ==Introduction== | ||
| - | + | Saves cells from dying since the appearance of life | |
Outline: | Outline: | ||
1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam. | 1) Why is it important? Penicillin-binding proteins are essential for cell wall biogenesis. General info about bacterial cell wall biogenesis. Also, how bacteria mutate in order to avoid binding to beta-lactam. | ||
2) Ligands, in particular <scene name='48/483886/Lactivicin/2'>phenoxyacetyl lactivicin</scene>. Also, how PBP binds lactivicin. | 2) Ligands, in particular <scene name='48/483886/Lactivicin/2'>phenoxyacetyl lactivicin</scene>. Also, how PBP binds lactivicin. | ||
Sample green scene: Penicillin-binding protein has four ligands, one of which is <scene name='48/483886/Edo_ligand/1'>the electron-deficient olefin ligand or EDO</scene> | Sample green scene: Penicillin-binding protein has four ligands, one of which is <scene name='48/483886/Edo_ligand/1'>the electron-deficient olefin ligand or EDO</scene> | ||
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==Overall Structure= | ==Overall Structure= | ||
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Ligand has oxyanion hole to further binding potential. How does this help? | Ligand has oxyanion hole to further binding potential. How does this help? | ||
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| - | <Structure load='2jch' size='300' frame='true' align='right' caption='2jch, insert caption here' scene='Insert optional scene name here' /> | ||
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==Binding Interactions== | ==Binding Interactions== | ||
| - | <Structure load='1a84' size='300' frame='true' align='right' caption='2jch, Insert caption here' scene='Insert optional scene name here' /> | ||
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==Additional Features== | ==Additional Features== | ||
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'''3)work as enzyme to catalyze synthesis of peptidoglycan''' | '''3)work as enzyme to catalyze synthesis of peptidoglycan''' | ||
| - | <Structure load='2jch' size='300' frame='true' align='right' caption='2jch, Insert caption here' scene='Insert optional scene name here' /> | ||
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==Quiz Question 1== | ==Quiz Question 1== | ||
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Shows the <scene name='48/483886/Conserved_residues_of_pbp/2'>conserved residues of Penicillin Binding Protein</scene> from most conserved to most variable.{{Template:ColorKey_ConSurf}} | Shows the <scene name='48/483886/Conserved_residues_of_pbp/2'>conserved residues of Penicillin Binding Protein</scene> from most conserved to most variable.{{Template:ColorKey_ConSurf}} | ||
| - | <Structure load='1a84' size='300' frame='true' align='right' caption='2jch, Insert caption here' scene='Insert optional scene name here' /> | ||
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==See Also== | ==See Also== | ||
Revision as of 21:57, 2 March 2016
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Penicillin binding protein/lactivicin (inhibitor) (2jch)[1]
by Tyler Carpenter, Samuel Pierce, Hyunjoon Choi, Anton El Khoury and Tiankai Zhang
Student Projects for UMass Chemistry 423 Spring 2016
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