1gg2

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[[Image:1gg2.gif|left|200px]]
[[Image:1gg2.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1gg2| PDB=1gg2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gg2 OCA], [http://www.ebi.ac.uk/pdbsum/1gg2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gg2 RCSB]</span>
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'''G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND'''
'''G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND'''
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[[Category: Sprang, S R.]]
[[Category: Sprang, S R.]]
[[Category: Wall, M A.]]
[[Category: Wall, M A.]]
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[[Category: complex (gtp-binding/transducer)]]
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[[Category: G protein]]
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[[Category: g protein]]
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[[Category: Gtpase]]
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[[Category: gtpase]]
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[[Category: Propeller]]
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[[Category: propeller]]
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[[Category: Ra]]
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[[Category: ra]]
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[[Category: Signal transduction protein]]
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[[Category: signal transduction protein]]
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[[Category: Wd40]]
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[[Category: wd40]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:31:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:43:23 2008''
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Revision as of 14:31, 2 May 2008

Image:1gg2.gif

Template:STRUCTURE 1gg2

G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND


Overview

The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.

About this Structure

1GG2 is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. The following page contains interesting information on the relation of 1GG2 with [G Proteins]. Full crystallographic information is available from OCA.

Reference

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2., Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR, Cell. 1995 Dec 15;83(6):1047-58. PMID:8521505 Page seeded by OCA on Fri May 2 17:31:06 2008

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