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1gg2
From Proteopedia
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[[Image:1gg2.gif|left|200px]] | [[Image:1gg2.gif|left|200px]] | ||
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'''G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND''' | '''G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND''' | ||
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[[Category: Sprang, S R.]] | [[Category: Sprang, S R.]] | ||
[[Category: Wall, M A.]] | [[Category: Wall, M A.]] | ||
| - | [[Category: | + | [[Category: G protein]] |
| - | + | [[Category: Gtpase]] | |
| - | [[Category: | + | [[Category: Propeller]] |
| - | [[Category: | + | [[Category: Ra]] |
| - | [[Category: | + | [[Category: Signal transduction protein]] |
| - | [[Category: | + | [[Category: Wd40]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:31:06 2008'' |
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Revision as of 14:31, 2 May 2008
G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
Overview
The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.
About this Structure
1GG2 is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. The following page contains interesting information on the relation of 1GG2 with [G Proteins]. Full crystallographic information is available from OCA.
Reference
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2., Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR, Cell. 1995 Dec 15;83(6):1047-58. PMID:8521505 Page seeded by OCA on Fri May 2 17:31:06 2008
