1ghe
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1ghe.gif|left|200px]] | [[Image:1ghe.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1ghe", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | | | + | {{STRUCTURE_1ghe| PDB=1ghe | SCENE= }} |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN COMPLEXED WITH AN ACYL COENZYME A''' | '''CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN COMPLEXED WITH AN ACYL COENZYME A''' | ||
| Line 37: | Line 34: | ||
[[Category: Zhang, R.]] | [[Category: Zhang, R.]] | ||
[[Category: Zhao, N.]] | [[Category: Zhao, N.]] | ||
| - | [[Category: | + | [[Category: Acyl coenzyme a complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:33:44 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:33, 2 May 2008
CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN COMPLEXED WITH AN ACYL COENZYME A
Overview
Tabtoxin resistance protein (TTR) is an enzyme that renders tabtoxin-producing pathogens, such as Pseudomonas syringae, tolerant to their own phytotoxins. Here, we report the crystal structure of TTR complexed with its natural cofactor, acetyl coenzyme A (AcCoA), to 1.55A resolution. The binary complex forms a characteristic "V" shape for substrate binding and contains the four motifs conserved in the GCN5-related N-acetyltransferase (GNAT) superfamily, which also includes the histone acetyltransferases (HATs). A single-step mechanism is proposed to explain the function of three conserved residues, Glu92, Asp130 and Tyr141, in catalyzing the acetyl group transfer to its substrate. We also report that TTR possesses HAT activity and suggest an evolutionary relationship between TTR and other GNAT members.
About this Structure
1GHE is a Single protein structure of sequence from Pseudomonas syringae pv. tabaci. Full crystallographic information is available from OCA.
Reference
Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation., He H, Ding Y, Bartlam M, Sun F, Le Y, Qin X, Tang H, Zhang R, Joachimiak A, Liu J, Zhao N, Rao Z, J Mol Biol. 2003 Jan 31;325(5):1019-30. PMID:12527305 Page seeded by OCA on Fri May 2 17:33:44 2008
Categories: Pseudomonas syringae pv. tabaci | Single protein | Bartlam, M. | Ding, Y. | He, H. | Joachimiak, A. | Le, Y. | Liu, Y. | Qin, X. | Rao, Z. | Sun, F. | Tang, H. | Zhang, R. | Zhao, N. | Acyl coenzyme a complex
