1gid

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[[Image:1gid.jpg|left|200px]]
[[Image:1gid.jpg|left|200px]]
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{{Structure
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|PDB= 1gid |SIZE=350|CAPTION= <scene name='initialview01'>1gid</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_1gid", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1gid| PDB=1gid | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gid OCA], [http://www.ebi.ac.uk/pdbsum/1gid PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gid RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING'''
'''CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING'''
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==About this Structure==
==About this Structure==
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1GID is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GID OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GID OCA].
==Reference==
==Reference==
Crystal structure of a group I ribozyme domain: principles of RNA packing., Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA, Science. 1996 Sep 20;273(5282):1678-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8781224 8781224]
Crystal structure of a group I ribozyme domain: principles of RNA packing., Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA, Science. 1996 Sep 20;273(5282):1678-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8781224 8781224]
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[[Category: Protein complex]]
 
[[Category: Cate, J H.]]
[[Category: Cate, J H.]]
[[Category: Cech, T R.]]
[[Category: Cech, T R.]]
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[[Category: Podell, E.]]
[[Category: Podell, E.]]
[[Category: Zhou, K.]]
[[Category: Zhou, K.]]
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[[Category: p4-p6 ribozyme domain of the tetrahymena group i intron]]
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[[Category: P4-p6 ribozyme domain of the tetrahymena group i intron]]
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[[Category: rna]]
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[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:36:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:44:40 2008''
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Revision as of 14:36, 2 May 2008

Image:1gid.jpg

Template:STRUCTURE 1gid

CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING


Overview

Group I self-splicing introns catalyze their own excision from precursor RNAs by way of a two-step transesterification reaction. The catalytic core of these ribozymes is formed by two structural domains. The 2.8-angstrom crystal structure of one of these, the P4-P6 domain of the Tetrahymena thermophila intron, is described. In the 160-nucleotide domain, a sharp bend allows stacked helices of the conserved core to pack alongside helices of an adjacent region. Two specific long-range interactions clamp the two halves of the domain together: a two-Mg2+-coordinated adenosine-rich corkscrew plugs into the minor groove of a helix, and a GAAA hairpin loop binds to a conserved 11-nucleotide internal loop. Metal- and ribose-mediated backbone contacts further stabilize the close side-by-side helical packing. The structure indicates the extent of RNA packing required for the function of large ribozymes, the spliceosome, and the ribosome.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a group I ribozyme domain: principles of RNA packing., Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA, Science. 1996 Sep 20;273(5282):1678-85. PMID:8781224 Page seeded by OCA on Fri May 2 17:36:46 2008

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