User:Christopher Berndsen/Labinfo
From Proteopedia
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== Research Highlights == | == Research Highlights == | ||
| - | Ubiquitin and Ubiquitin-like proteins are linked to many cellular functions included protein degradation and DNA damage repair <ref>PMID:15571809<ref><ref>PMID:24699078<ref>. The Berndsen Lab is interested in the catalytic mechanisms the conjugating enzymes E1, E2, and E3 use to attach ubiquitin/ubiquitin-like proteins to the substrate lysine. We are also interested in the proteases that remove these modifications and the chemical mechanism(s) of catalysis. We are currently focusing on UFM1<Structure load='1WXS' size='350' frame='true' align='right' caption='NMR Structure of UFM1 from <ref>PMID:16527251<ref>' scene='UFM1' /> | + | Ubiquitin and Ubiquitin-like proteins are linked to many cellular functions included protein degradation and DNA damage repair <ref>PMID:15571809</ref><ref>PMID:24699078</ref>. The Berndsen Lab is interested in the catalytic mechanisms the conjugating enzymes E1, E2, and E3 use to attach ubiquitin/ubiquitin-like proteins to the substrate lysine. We are also interested in the proteases that remove these modifications and the chemical mechanism(s) of catalysis. We are currently focusing on UFM1<Structure load='1WXS' size='350' frame='true' align='right' caption='NMR Structure of UFM1 from <ref>PMID:16527251</ref>' scene='UFM1' /> |
== Disease == | == Disease == | ||
Revision as of 19:42, 1 March 2016
The Berndsen Laboratory at James Madison University
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References
- ↑ Pickart CM, Eddins MJ. Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta. 2004 Nov 29;1695(1-3):55-72. PMID:15571809 doi:http://dx.doi.org/10.1016/j.bbamcr.2004.09.019
- ↑ Berndsen CE, Wolberger C. New insights into ubiquitin E3 ligase mechanism. Nat Struct Mol Biol. 2014 Apr;21(4):301-7. doi: 10.1038/nsmb.2780. PMID:24699078 doi:http://dx.doi.org/10.1038/nsmb.2780
