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Ferrochelatase

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Defective FECH is the cause of erythropoietic protoporphyria (EPP), an inherited disorder of heme synthesis <ref>PMID 11929052</ref>.
Defective FECH is the cause of erythropoietic protoporphyria (EPP), an inherited disorder of heme synthesis <ref>PMID 11929052</ref>.
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'''Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of ''Bacillus subtilis'' ferrochelatase <ref>DOI 10.1007/s00775-010-0720-4</ref>'''
'''Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of ''Bacillus subtilis'' ferrochelatase <ref>DOI 10.1007/s00775-010-0720-4</ref>'''

Revision as of 09:15, 2 March 2016

Ferrochelatase with methylmesoporphyrin and Mg+2 ion (PDB code 1c1h)

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3D structures of ferrochelatase

Updated on 02-March-2016

References

  1. Chen FP, Risheg H, Liu Y, Bloomer J. Ferrochelatase gene mutations in erythropoietic protoporphyria: focus on liver disease. Cell Mol Biol (Noisy-le-grand). 2002 Feb;48(1):83-9. PMID:11929052
  2. Hansson MD, Karlberg T, Soderberg CA, Rajan S, Warren MJ, Al-Karadaghi S, Rigby SE, Hansson M. Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase. J Biol Inorg Chem. 2010 Nov 4. PMID:21052751 doi:10.1007/s00775-010-0720-4

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