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Forkhead box protein

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{{STRUCTURE_3co6| PDB=3co6 | SIZE=350| SCENE= |right|CAPTION=Human FoxO1 DNA-binding domain complex with DNA, Ca+2 and chloride ions, [[3co6]] }}
{{STRUCTURE_3co6| PDB=3co6 | SIZE=350| SCENE= |right|CAPTION=Human FoxO1 DNA-binding domain complex with DNA, Ca+2 and chloride ions, [[3co6]] }}
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'''Forkhead box proteins''' (FOX) are transcription factors involved in regulation of gene expression. They contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape<ref>PMID:17889656</ref>. For details on individual FOX proteins, see <br />
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== Function ==
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'''Forkhead box proteins''' (FOX) are transcription factors involved in regulation of gene expression.<ref>PMID:17889656</ref>. For details on individual FOX proteins, see <br />
*[[FOXP2]]<br />
*[[FOXP2]]<br />
*[[Foxp2 bound specifically to DNA]]<br />
*[[Foxp2 bound specifically to DNA]]<br />
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[[Transcription and RNA Processing]]<br />
[[Transcription and RNA Processing]]<br />
[[Neurodevelopmental Disorders]].
[[Neurodevelopmental Disorders]].
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== Disease ==
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FOX mutations are implicated in congenital heart disease<ref>PMID:26656470</ref>.
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== Structural highlights ==
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FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape.
==3D structures of FOX==
==3D structures of FOX==

Revision as of 10:34, 2 March 2016

Template:STRUCTURE 3co6

Contents

Function

Forkhead box proteins (FOX) are transcription factors involved in regulation of gene expression.[1]. For details on individual FOX proteins, see

See also
Transcription and RNA Processing
Neurodevelopmental Disorders.

Disease

FOX mutations are implicated in congenital heart disease[2].

Structural highlights

FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape.

3D structures of FOX

Updated on 02-March-2016

References

  1. ↑ Tuteja G, Kaestner KH. SnapShot: forkhead transcription factors I. Cell. 2007 Sep 21;130(6):1160. PMID:17889656 doi:http://dx.doi.org/10.1016/j.cell.2007.09.005
  2. ↑ Zhu H. Forkhead box transcription factors in embryonic heart development and congenital heart disease. Life Sci. 2016 Jan 1;144:194-201. doi: 10.1016/j.lfs.2015.12.001. Epub 2015 Dec, 2. PMID:26656470 doi:http://dx.doi.org/10.1016/j.lfs.2015.12.001

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