5hdh
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human TLR8 with an uncleaved Z-loop== | |
| - | + | <StructureSection load='5hdh' size='340' side='right' caption='[[5hdh]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hdh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HDH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HDH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hdh OCA], [http://pdbe.org/5hdh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hdh RCSB], [http://www.ebi.ac.uk/pdbsum/5hdh PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ohto, U]] | ||
| + | [[Category: Shimizu, T]] | ||
[[Category: Tanji, H]] | [[Category: Tanji, H]] | ||
| - | [[Category: | + | [[Category: Immune system]] |
| - | [[Category: | + | [[Category: Innate immunity]] |
| + | [[Category: Proteolytic cleavage]] | ||
| + | [[Category: Tlr8]] | ||
Revision as of 03:58, 10 March 2016
Crystal structure of human TLR8 with an uncleaved Z-loop
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