1gl4

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[[Image:1gl4.jpg|left|200px]]
[[Image:1gl4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1gl4 |SIZE=350|CAPTION= <scene name='initialview01'>1gl4</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1gl4", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=EPE:Zn+Binding+Site+For+Chain+A+Symmetry+Related+Subunits+Co+...'>EPE</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1gl4| PDB=1gl4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl4 OCA], [http://www.ebi.ac.uk/pdbsum/1gl4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gl4 RCSB]</span>
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}}
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'''NIDOGEN-1 G2/PERLECAN IG3 COMPLEX'''
'''NIDOGEN-1 G2/PERLECAN IG3 COMPLEX'''
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[[Category: Ries, A.]]
[[Category: Ries, A.]]
[[Category: Timpl, R.]]
[[Category: Timpl, R.]]
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[[Category: basement membrane]]
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[[Category: Basement membrane]]
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[[Category: extracellular matrix]]
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[[Category: Extracellular matrix]]
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[[Category: heparan sulfate]]
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[[Category: Heparan sulfate]]
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[[Category: immunoglobulin-like domain]]
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[[Category: Immunoglobulin-like domain]]
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[[Category: proteoglycan]]
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[[Category: Proteoglycan]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:42:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:46:19 2008''
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Revision as of 14:42, 2 May 2008

Image:1gl4.jpg

Template:STRUCTURE 1gl4

NIDOGEN-1 G2/PERLECAN IG3 COMPLEX


Overview

Nidogen and perlecan are large multifunctional basement membrane (BM) proteins conserved in all metazoa. Their high-affinity interaction, which is likely to contribute to BM assembly and function, is mediated by the central G2 domain in nidogen and the third immunoglobulin (IG)-like domain in perlecan, IG3. We have solved the crystal structure at 2.0 A resolution of the mouse nidogen-1 G2-perlecan IG3 complex. Perlecan IG3 belongs to the I-set of the IG superfamily and binds to the wall of the nidogen-1 G2 beta-barrel using beta-strands C, D and F. Nidogen-1 residues participating in the extensive interface are highly conserved, whereas the corresponding binding site on perlecan is more variable. We hypothesize that a second, as yet unidentified, activity of nidogen overlaps with perlecan binding and accounts for the unusually high degree of surface conservation in the G2 domain.

About this Structure

1GL4 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan., Kvansakul M, Hopf M, Ries A, Timpl R, Hohenester E, EMBO J. 2001 Oct 1;20(19):5342-6. PMID:11574465 Page seeded by OCA on Fri May 2 17:42:43 2008

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