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1gl4
From Proteopedia
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[[Image:1gl4.jpg|left|200px]] | [[Image:1gl4.jpg|left|200px]] | ||
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'''NIDOGEN-1 G2/PERLECAN IG3 COMPLEX''' | '''NIDOGEN-1 G2/PERLECAN IG3 COMPLEX''' | ||
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[[Category: Ries, A.]] | [[Category: Ries, A.]] | ||
[[Category: Timpl, R.]] | [[Category: Timpl, R.]] | ||
| - | [[Category: | + | [[Category: Basement membrane]] |
| - | [[Category: | + | [[Category: Extracellular matrix]] |
| - | [[Category: | + | [[Category: Heparan sulfate]] |
| - | [[Category: | + | [[Category: Immunoglobulin-like domain]] |
| - | [[Category: | + | [[Category: Proteoglycan]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:42:43 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:42, 2 May 2008
NIDOGEN-1 G2/PERLECAN IG3 COMPLEX
Overview
Nidogen and perlecan are large multifunctional basement membrane (BM) proteins conserved in all metazoa. Their high-affinity interaction, which is likely to contribute to BM assembly and function, is mediated by the central G2 domain in nidogen and the third immunoglobulin (IG)-like domain in perlecan, IG3. We have solved the crystal structure at 2.0 A resolution of the mouse nidogen-1 G2-perlecan IG3 complex. Perlecan IG3 belongs to the I-set of the IG superfamily and binds to the wall of the nidogen-1 G2 beta-barrel using beta-strands C, D and F. Nidogen-1 residues participating in the extensive interface are highly conserved, whereas the corresponding binding site on perlecan is more variable. We hypothesize that a second, as yet unidentified, activity of nidogen overlaps with perlecan binding and accounts for the unusually high degree of surface conservation in the G2 domain.
About this Structure
1GL4 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan., Kvansakul M, Hopf M, Ries A, Timpl R, Hohenester E, EMBO J. 2001 Oct 1;20(19):5342-6. PMID:11574465 Page seeded by OCA on Fri May 2 17:42:43 2008
