1gl2
From Proteopedia
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'''CRYSTAL STRUCTURE OF AN ENDOSOMAL SNARE CORE COMPLEX''' | '''CRYSTAL STRUCTURE OF AN ENDOSOMAL SNARE CORE COMPLEX''' | ||
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[[Category: Jahn, R.]] | [[Category: Jahn, R.]] | ||
[[Category: Schneider, T R.]] | [[Category: Schneider, T R.]] | ||
| - | [[Category: | + | [[Category: Coiled coil]] |
| - | [[Category: | + | [[Category: Membrane fusion protein complex]] |
| - | [[Category: | + | [[Category: Transmembrane]] |
| - | [[Category: | + | [[Category: Transport]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:42:44 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:42, 2 May 2008
CRYSTAL STRUCTURE OF AN ENDOSOMAL SNARE CORE COMPLEX
Overview
SNARE proteins are crucial for intracellular membrane fusion in all eukaryotes. These proteins assemble into tight complexes that connect membranes and may induce fusion. The crystal structure of the neuronal core complex is represented by an unusually long bundle of four alpha-helices connected by 16 layers of mostly hydrophobic amino acids. Here we report the 1.9 A resolution crystal structure of an endosomal SNARE core complex containing four SNAREs: syntaxin 7, syntaxin 8, vti1b and endobrevin/VAMP-8. Despite limited sequence homology, the helix alignment and the layer structure of the endosomal complex are remarkably similar to those of the neuronal complex. However, subtle variations are evident that characterize different SNARE subfamilies. We conclude that the structure of the SNARE core complex is an evolutionarily conserved hallmark of all SNARE complexes and is intimately associated with the general role of SNAREs in membrane fusion.
About this Structure
1GL2 is a Protein complex structure of sequences from Mus musculus and Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs., Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR, Nat Struct Biol. 2002 Feb;9(2):107-11. PMID:11786915 Page seeded by OCA on Fri May 2 17:42:44 2008
