1gme
From Proteopedia
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'''CRYSTAL STRUCTURE AND ASSEMBLY OF AN EUKARYOTIC SMALL HEAT SHOCK PROTEIN''' | '''CRYSTAL STRUCTURE AND ASSEMBLY OF AN EUKARYOTIC SMALL HEAT SHOCK PROTEIN''' | ||
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[[Category: Slingsby, C.]] | [[Category: Slingsby, C.]] | ||
[[Category: Vierling, E.]] | [[Category: Vierling, E.]] | ||
| - | [[Category: | + | [[Category: Alpha-crystallin]] |
| - | [[Category: | + | [[Category: Chaperone]] |
| - | [[Category: | + | [[Category: Small heat shock protein]] |
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Revision as of 14:44, 2 May 2008
CRYSTAL STRUCTURE AND ASSEMBLY OF AN EUKARYOTIC SMALL HEAT SHOCK PROTEIN
Overview
The 2.7 A structure of wheat HSP16.9, a member of the small heat shock proteins (sHSPs), indicates how its alpha-crystallin domain and flanking extensions assemble into a dodecameric double disk. The folding of the monomer and assembly of the oligomer are mutually interdependent, involving strand exchange, helix swapping, loose knots and hinged extensions. In support of the chaperone mechanism, the substrate-bound dimers, in temperature-dependent equilibrium with higher assembly forms, have unfolded N-terminal arms and exposed conserved hydrophobic binding sites on the alpha-crystallin domain. The structure also provides a model by which members of the sHSP protein family bind unfolded substrates, which are involved in a variety of neurodegenerative diseases and cataract formation.
About this Structure
1GME is a Single protein structure of sequence from Triticum aestivum. Full crystallographic information is available from OCA.
Reference
Crystal structure and assembly of a eukaryotic small heat shock protein., van Montfort RL, Basha E, Friedrich KL, Slingsby C, Vierling E, Nat Struct Biol. 2001 Dec;8(12):1025-30. PMID:11702068 Page seeded by OCA on Fri May 2 17:44:56 2008
