1gp7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1gp7.gif|left|200px]]
[[Image:1gp7.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1gp7 |SIZE=350|CAPTION= <scene name='initialview01'>1gp7</scene>, resolution 2.6&Aring;
+
The line below this paragraph, containing "STRUCTURE_1gp7", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=CAA:Ca+Binding+Site+For+Chain+C'>CAA</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1gp7| PDB=1gp7 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gp7 OCA], [http://www.ebi.ac.uk/pdbsum/1gp7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gp7 RCSB]</span>
+
-
}}
+
'''ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH'''
'''ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH'''
Line 24: Line 21:
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12217659 12217659]
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12217659 12217659]
[[Category: Ophiophagus hannah]]
[[Category: Ophiophagus hannah]]
-
[[Category: Phospholipase A(2)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Lin, Z.]]
[[Category: Lin, Z.]]
[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
-
[[Category: calcium]]
+
[[Category: Calcium]]
-
[[Category: cardiotoxic activity]]
+
[[Category: Cardiotoxic activity]]
-
[[Category: crystal structure]]
+
[[Category: Crystal structure]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: king cobra]]
+
[[Category: King cobra]]
-
[[Category: lipid degradation]]
+
[[Category: Lipid degradation]]
-
[[Category: myotoxic activity]]
+
[[Category: Myotoxic activity]]
-
[[Category: pancreatic loop]]
+
[[Category: Pancreatic loop]]
-
[[Category: phospholipase a2]]
+
[[Category: Phospholipase a2]]
-
[[Category: snake venom]]
+
[[Category: Snake venom]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:50:49 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:48:36 2008''
+

Revision as of 14:50, 2 May 2008

Image:1gp7.gif

Template:STRUCTURE 1gp7

ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH


Overview

The crystal structure of an acidic phospholipase A(2) from Ophiophagus hannah (king cobra) has been determined by molecular replacement at 2.6-A resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with reasonable stereochemistry. The venom enzyme contains an unusual "pancreatic loop." The conformation of the loop is well defined and different from those in pancreas PLA(2), showing its structural variability. This analysis provides the first structure of a PLA(2)-type cardiotoxin. The sites related to the cardiotoxic and myotoxic activities are explored and the oligomer observed in the crystalline state is described.

About this Structure

1GP7 is a Single protein structure of sequence from Ophiophagus hannah. Full crystallographic information is available from OCA.

Reference

Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:12217659 Page seeded by OCA on Fri May 2 17:50:49 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gp7"
Personal tools