Sandbox Reserved 430
From Proteopedia
(Difference between revisions)
(Undo revision 2580025 by Lynmarie K Thompson (Talk)) |
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[[Student Projects for UMass Chemistry 423 Spring 2016]] | [[Student Projects for UMass Chemistry 423 Spring 2016]] | ||
| + | <StructureSection load='4ntj' size='350' side='right' caption='caption for Molecular Playground (PDB entry [[4ntj]])' scene=''> | ||
==Introduction== | ==Introduction== | ||
| - | <Structure load='4ntj' size='300' frame='true' align='right' caption='4ntj, Insert caption here' scene='Insert optional scene name here' /> | ||
<scene name='48/483887/Secondary_structure/1'>Secondary Structure</scene>. | <scene name='48/483887/Secondary_structure/1'>Secondary Structure</scene>. | ||
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A)P2Y receptors are a subunit of a catergory of purinergic G-protein-coupled receptors | A)P2Y receptors are a subunit of a catergory of purinergic G-protein-coupled receptors | ||
| - | + | Cell receptors have specificity for ATP or ADP over adenosine | |
| - | + | P2Y12-->platelet activation and thrombus formation | |
| - | + | Drugs Candidates - engineered molecules (allosteric regulators) that can inhibit P2Y12 receptors through conformational change and active site inhibition. | |
B) Plavix, Effient, and Brilinta | B) Plavix, Effient, and Brilinta | ||
| - | + | Effects on P2Y12 | |
C)ADZ1283 - Binding and Pocket Chemistry | C)ADZ1283 - Binding and Pocket Chemistry | ||
D) Differences between P2Y12r with and without ADZ1283 | D) Differences between P2Y12r with and without ADZ1283 | ||
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Note: Green Scene still to come | Note: Green Scene still to come | ||
| - | <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | ||
==Overall Structure== | ==Overall Structure== | ||
| - | <Structure load='4ntj' size='300' frame='true' align='right' caption='4ntj, Overall Structure' scene='Insert optional scene name here' /> | ||
The <scene name='48/483887/Secondary_structure/2'>TextToBeDisplayed</scene> is mostly made up of alpha helices, shown in pink. The beta strands are shown in yellow. Polar vs nonpolar:Polar regions are pink. Nonpolar, or hyrophobic, regions are grey. <scene name='48/483887/Polar__nonpolar/1'>TextToBeDisplayed</scene> | The <scene name='48/483887/Secondary_structure/2'>TextToBeDisplayed</scene> is mostly made up of alpha helices, shown in pink. The beta strands are shown in yellow. Polar vs nonpolar:Polar regions are pink. Nonpolar, or hyrophobic, regions are grey. <scene name='48/483887/Polar__nonpolar/1'>TextToBeDisplayed</scene> | ||
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==Binding Interactions== | ==Binding Interactions== | ||
| - | <Structure load='4ntj' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='Insert optional scene name here' /> | ||
The <scene name='48/483887/Binding_site/4'>Binding Site</scene> of P2Y12 is colored in purple, which is the burried site, along with the ligands, which is colored in yellow. | The <scene name='48/483887/Binding_site/4'>Binding Site</scene> of P2Y12 is colored in purple, which is the burried site, along with the ligands, which is colored in yellow. | ||
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==Additional Features== | ==Additional Features== | ||
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==Quiz Question 1== | ==Quiz Question 1== | ||
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==See Also== | ==See Also== | ||
Revision as of 22:09, 2 March 2016
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
P2Y12 Receptor in Complex with Clopidogrel (4ntj)[1]
by [Cora Ricker, Lauren Timmins, Aidan Finnerty, Adam Murphy, Duy Nguyen]
Student Projects for UMass Chemistry 423 Spring 2016
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