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1gql

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[[Image:1gql.gif|left|200px]]
[[Image:1gql.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1gql |SIZE=350|CAPTION= <scene name='initialview01'>1gql</scene>, resolution 1.67&Aring;
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The line below this paragraph, containing "STRUCTURE_1gql", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Xyp+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BDP:BETA-D-GALACTOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucuronidase Alpha-glucuronidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.139 3.2.1.139] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1gql| PDB=1gql | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gql OCA], [http://www.ebi.ac.uk/pdbsum/1gql PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gql RCSB]</span>
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}}
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'''STRUCTURE OF PSEUDOMONAS CELLULOSA ALPHA-D-GLUCURONIDASE COMPLEXED WITH GLUCURONIC ACID AND XYLOTRIOSE'''
'''STRUCTURE OF PSEUDOMONAS CELLULOSA ALPHA-D-GLUCURONIDASE COMPLEXED WITH GLUCURONIC ACID AND XYLOTRIOSE'''
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[[Category: Nagy, T.]]
[[Category: Nagy, T.]]
[[Category: Nurizzo, D.]]
[[Category: Nurizzo, D.]]
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[[Category: (alpha-beta)8 barrel]]
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[[Category: Glucuronic acid]]
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[[Category: glucuronic acid]]
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[[Category: Glucuronidase]]
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[[Category: glucuronidase]]
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[[Category: Glycoside hydrolase]]
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[[Category: glycoside hydrolase]]
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[[Category: Structure]]
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[[Category: structure]]
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[[Category: Xylotriose]]
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[[Category: xylotriose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:53:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:49:30 2008''
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Revision as of 14:53, 2 May 2008

Image:1gql.gif

Template:STRUCTURE 1gql

STRUCTURE OF PSEUDOMONAS CELLULOSA ALPHA-D-GLUCURONIDASE COMPLEXED WITH GLUCURONIC ACID AND XYLOTRIOSE


Overview

Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. The structure of the alpha-glucuronidase, GlcA67A, from Pseudomonas cellulosa reveals three domains, the central of which is a (beta/alpha)(8) barrel housing the catalytic apparatus. Complexes of the enzyme with the individual reaction products, either xylobiose or glucuronic acid, and the ternary complex of both glucuronic acid and xylotriose reveal a "blind" pocket which selects for short decorated xylooligosaccharides substituted with the uronic acid at their nonreducing end, consistent with kinetic data. The catalytic center reveals a constellation of carboxylates; Glu292 is poised to provide protonic assistance to leaving group departure with Glu393 and Asp365 both appropriately positioned to provide base-catalyzed assistance for inverting nucleophilic attack by water.

About this Structure

1GQL is a Single protein structure of sequence from Cellvibrio japonicus. Full crystallographic information is available from OCA.

Reference

The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A., Nurizzo D, Nagy T, Gilbert HJ, Davies GJ, Structure. 2002 Apr;10(4):547-56. PMID:11937059 Page seeded by OCA on Fri May 2 17:53:45 2008

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