This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5crz
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand== | ==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand== | ||
| - | <StructureSection load='5crz' size='340' side='right' caption='[[5crz]], [[Resolution|resolution]] 2.12Å' scene=''> | + | <StructureSection load='5crz' size='340' side='right'caption='[[5crz]], [[Resolution|resolution]] 2.12Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5crz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CRZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5crz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CRZ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB7:2-CHLORO-N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)-4-FLUOROBENZENESULFONAMIDE'>EB7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB7:2-CHLORO-N-(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)-4-FLUOROBENZENESULFONAMIDE'>EB7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cp5|5cp5]], [[5cpe|5cpe]], [[5cqt|5cqt]], [[5coi|5coi]], [[5crm|5crm]], [[5cs8|5cs8]], [[5ctl|5ctl]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cp5|5cp5]], [[5cpe|5cpe]], [[5cqt|5cqt]], [[5coi|5coi]], [[5crm|5crm]], [[5cs8|5cs8]], [[5ctl|5ctl]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5crz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5crz OCA], [http://pdbe.org/5crz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5crz RCSB], [http://www.ebi.ac.uk/pdbsum/5crz PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5crz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5crz OCA], [http://pdbe.org/5crz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5crz RCSB], [http://www.ebi.ac.uk/pdbsum/5crz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5crz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| Line 23: | Line 24: | ||
==See Also== | ==See Also== | ||
| - | *[[Bromodomain-containing protein|Bromodomain-containing protein]] | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Liu, Z]] | [[Category: Liu, Z]] | ||
[[Category: Song, M]] | [[Category: Song, M]] | ||
Revision as of 10:21, 1 April 2020
Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
| |||||||||||
