5a7c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the second bromodomain of human BRD3 in complex with compound== | |
| - | + | <StructureSection load='5a7c' size='340' side='right' caption='[[5a7c]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5a7c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A7C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5D4:N-(6-ACETAMIDOHEXYL)ACETAMIDE'>5D4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a6n|5a6n]], [[5a6o|5a6o]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a7c OCA], [http://pdbe.org/5a7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a7c RCSB], [http://www.ebi.ac.uk/pdbsum/5a7c PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Diehl, C]] | ||
| + | [[Category: Hakansson, M]] | ||
[[Category: Kimbung, R]] | [[Category: Kimbung, R]] | ||
| + | [[Category: Logan, D T]] | ||
[[Category: Walse, B]] | [[Category: Walse, B]] | ||
[[Category: Welin, M]] | [[Category: Welin, M]] | ||
| - | [[Category: | + | [[Category: Brd3]] |
| - | [[Category: | + | [[Category: Brd3 domain 2]] |
| + | [[Category: Bromodomain containing protein 3]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Ring3-like protein]] | ||
Revision as of 03:46, 11 May 2016
Crystal structure of the second bromodomain of human BRD3 in complex with compound
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