1grn

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[[Image:1grn.jpg|left|200px]]
[[Image:1grn.jpg|left|200px]]
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{{Structure
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|PDB= 1grn |SIZE=350|CAPTION= <scene name='initialview01'>1grn</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1grn", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_1grn| PDB=1grn | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1grn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1grn OCA], [http://www.ebi.ac.uk/pdbsum/1grn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1grn RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX.'''
'''CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX.'''
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[[Category: Hoffman, G R.]]
[[Category: Hoffman, G R.]]
[[Category: Nassar, N.]]
[[Category: Nassar, N.]]
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[[Category: alf3]]
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[[Category: Alf3]]
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[[Category: cdc42]]
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[[Category: Cdc42]]
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[[Category: g-protein]]
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[[Category: G-protein]]
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[[Category: gap]]
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[[Category: Gap]]
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[[Category: transition-state]]
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[[Category: Transition-state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:55:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:49:56 2008''
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Revision as of 14:55, 2 May 2008

Image:1grn.jpg

Template:STRUCTURE 1grn

CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX.


Overview

The Rho-related small GTP-binding protein Cdc42 has a low intrinsic GTPase activity that is significantly enhanced by its specific GTPase-activating protein, Cdc42GAP. In this report, we present the tertiary structure for the aluminum fluoride-promoted complex between Cdc42 and a catalytically active domain of Cdc42GAP as well as the complex between Cdc42 and the catalytically compromised Cdc42GAP(R305A) mutant. These structures, which mimic the transition state for the GTP hydrolytic reaction, show the presence of an AIF3 molecule, as was seen for the corresponding Ras-p120RasGAP complex, but in contrast to what has been reported for the Rho-Cdc42GAP complex or for heterotrimeric G protein alpha subunits, where AIF4- was observed. The Cdc42GAP stabilizes both the switch I and switch II domains of Cdc42 and contributes a highly conserved arginine (Arg 305) to the active site. Comparison of the structures for the wild type and mutant Cdc42GAP complexes provides important insights into the GAP-catalyzed GTP hydrolytic reaction.

About this Structure

1GRN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP., Nassar N, Hoffman GR, Manor D, Clardy JC, Cerione RA, Nat Struct Biol. 1998 Dec;5(12):1047-52. PMID:9846874 Page seeded by OCA on Fri May 2 17:55:46 2008

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