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5i0i
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state== | |
| - | + | <StructureSection load='5i0i' size='340' side='right' caption='[[5i0i]], [[Resolution|resolution]] 3.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i0i]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I0I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hmo|5hmo]], [[5hmp|5hmp]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0i OCA], [http://pdbe.org/5i0i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0i RCSB], [http://www.ebi.ac.uk/pdbsum/5i0i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Houdusse, A]] | ||
[[Category: Isabet, T]] | [[Category: Isabet, T]] | ||
| - | [[Category: | + | [[Category: Sweeney, H L]] |
| - | [[Category: | + | [[Category: Molecular motor]] |
| + | [[Category: Motility]] | ||
| + | [[Category: Motor domain]] | ||
| + | [[Category: Motor protein]] | ||
| + | [[Category: Myosin]] | ||
| + | [[Category: Pre-powerstrocke state]] | ||
Revision as of 21:07, 10 September 2016
Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state
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