1gv7

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[[Image:1gv7.gif|left|200px]]
[[Image:1gv7.gif|left|200px]]
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{{Structure
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|PDB= 1gv7 |SIZE=350|CAPTION= <scene name='initialview01'>1gv7</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1gv7", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Cit+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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{{STRUCTURE_1gv7| PDB=1gv7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv7 OCA], [http://www.ebi.ac.uk/pdbsum/1gv7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gv7 RCSB]</span>
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'''ARH-I, AN ANGIOGENIN/RNASE A CHIMERA'''
'''ARH-I, AN ANGIOGENIN/RNASE A CHIMERA'''
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[[Category: Leonidas, D D.]]
[[Category: Leonidas, D D.]]
[[Category: Shapiro, R.]]
[[Category: Shapiro, R.]]
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[[Category: angiogenesis]]
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[[Category: Angiogenesis]]
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[[Category: angiogenin]]
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[[Category: Angiogenin]]
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[[Category: chimera]]
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[[Category: Chimera]]
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[[Category: homolog scanning mutagenesis]]
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[[Category: Homolog scanning mutagenesis]]
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[[Category: hybrid]]
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[[Category: Hybrid]]
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[[Category: pancreatic ribonuclease]]
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[[Category: Pancreatic ribonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:03:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:52:00 2008''
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Revision as of 15:03, 2 May 2008

Image:1gv7.gif

Template:STRUCTURE 1gv7

ARH-I, AN ANGIOGENIN/RNASE A CHIMERA


Overview

Angiogenin and ribonuclease A share 33% sequence identity but have distinct functions. Angiogenin is a potent inducer of angiogenesis that is only weakly ribonucleolytic, whereas ribonuclease A is a robust ribonuclease that is not angiogenic. A chimera ("ARH-I"), in which angiogenin residues 58-70 are replaced with residues 59-73 of ribonuclease A, has intermediate ribonucleolytic potency and no angiogenic activity. Here we report a crystal structure of ARH-I that reveals the molecular basis for these characteristics. The ribonuclease A-derived (guest) segment adopts a structure largely similar to that in ribonuclease A, and successfully converts this region from a cell-binding site to a purine-binding site. At the same time, its presence causes complex changes in the angiogenin-derived (host) portion that account for much of the increased ribonuclease activity of ARH-I. Guest-host interactions of this type probably occur more generally in protein chimeras, emphasizing the importance of direct structural information for understanding the functional behavior of such molecules.

About this Structure

1GV7 is a Single protein structure of sequence from Homo sapiens, bos taurus. Full crystallographic information is available from OCA.

Reference

Guest-host crosstalk in an angiogenin-RNase A chimeric protein., Holloway DE, Shapiro R, Hares MC, Leonidas DD, Acharya KR, Biochemistry. 2002 Aug 20;41(33):10482-9. PMID:12173935 Page seeded by OCA on Fri May 2 18:03:03 2008

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