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1gwb

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[[Image:1gwb.gif|left|200px]]
[[Image:1gwb.gif|left|200px]]
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{{Structure
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|PDB= 1gwb |SIZE=350|CAPTION= <scene name='initialview01'>1gwb</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1gwb", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+B'>AC2</scene>
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STY:TYROSINE-O-SULPHONIC+ACID'>STY</scene>, <scene name='pdbligand=TYS:SULFONATED+TYROSINE'>TYS</scene>
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|ACTIVITY=
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|DOMAIN=
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{{STRUCTURE_1gwb| PDB=1gwb | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwb OCA], [http://www.ebi.ac.uk/pdbsum/1gwb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gwb RCSB]</span>
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'''STRUCTURE OF GLYCOPROTEIN 1B'''
'''STRUCTURE OF GLYCOPROTEIN 1B'''
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[[Category: Harrison, T.]]
[[Category: Harrison, T.]]
[[Category: Uff, S.]]
[[Category: Uff, S.]]
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[[Category: bernard soulier syndrome]]
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[[Category: Bernard soulier syndrome]]
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[[Category: blood coagulation]]
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[[Category: Blood coagulation]]
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[[Category: cell adhesion]]
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[[Category: Cell adhesion]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: glycoprotein 1b]]
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[[Category: Glycoprotein 1b]]
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[[Category: hemostasis]]
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[[Category: Hemostasis]]
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[[Category: leucine-rich repeat]]
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[[Category: Leucine-rich repeat]]
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[[Category: platelet]]
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[[Category: Platelet]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: repeat]]
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[[Category: Repeat]]
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[[Category: signal]]
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[[Category: Signal]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: von willebrand disease]]
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[[Category: Von willebrand disease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:05:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:52:39 2008''
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Revision as of 15:05, 2 May 2008

Image:1gwb.gif

Template:STRUCTURE 1gwb

STRUCTURE OF GLYCOPROTEIN 1B


Overview

Glycoprotein Ib (GPIb) is a platelet receptor with a critical role in mediating the arrest of platelets at sites of vascular damage. GPIb binds to the A1 domain of von Willebrand factor (vWF-A1) at high blood shear, initiating platelet adhesion and contributing to the formation of a thrombus. To investigate the molecular basis of GPIb regulation and ligand binding, we have determined the structure of the N-terminal domain of the GPIb(alpha) chain (residues 1-279). This structure is the first determined from the cell adhesion/signaling class of leucine-rich repeat (LRR) proteins and reveals the topology of the characteristic disulfide-bonded flanking regions. The fold consists of an N-terminal beta-hairpin, eight leucine-rich repeats, a disulfide-bonded loop, and a C-terminal anionic region. The structure also demonstrates a novel LRR motif in the form of an M-shaped arrangement of three tandem beta-turns. Negatively charged binding surfaces on the LRR concave face and anionic region indicate two-step binding kinetics to vWF-A1, which can be regulated by an unmasking mechanism involving conformational change of a key loop. Using molecular docking of the GPIb and vWF-A1 crystal structures, we were also able to model the GPIb.vWF-A1 complex.

About this Structure

1GWB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation., Uff S, Clemetson JM, Harrison T, Clemetson KJ, Emsley J, J Biol Chem. 2002 Sep 20;277(38):35657-63. Epub 2002 Jun 26. PMID:12087105 Page seeded by OCA on Fri May 2 18:05:28 2008

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