Glycerol kinase
From Proteopedia
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<StructureSection load='1xup' size='350' side='right' caption='Glycerol kinase complex with glycerol (PDB entry [[1xup]])' scene=''> | <StructureSection load='1xup' size='350' side='right' caption='Glycerol kinase complex with glycerol (PDB entry [[1xup]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID: | + | '''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID:10759857</ref>. |
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| + | == Disease == | ||
| + | GK Deficiency is an X-linked disease which has 3 forms: infantile, juvenile and adult<ref>PMID:15684452</ref> | ||
==3D structures of glycerol kinase== | ==3D structures of glycerol kinase== | ||
Revision as of 07:56, 13 March 2016
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