Glutaminase

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**[[3ss3]], [[3ss4]] – mGLN C – mouse<br />
**[[3ss3]], [[3ss4]] – mGLN C – mouse<br />
**[[4jkt]] - mGLN kidney isoform<br />
**[[4jkt]] - mGLN kidney isoform<br />
-
**[[3voy]] – hGLN kidney isoform – human<br />
+
**[[3voy]], [[5d3o]] – hGLN kidney isoform – human<br />
**[[4bqm]] - hGLN liver isoform<br />
**[[4bqm]] - hGLN liver isoform<br />
*GLN complex
*GLN complex
-
**[[3brm]] – BsGLN + norleucine <br />
+
**[[3brm]], [[2osu]] – BsGLN + norleucine derivative<br />
**[[3czd]], [[3unw]] – hGLN + Glu<br />
**[[3czd]], [[3unw]] – hGLN + Glu<br />
**[[3vp0]] – hGLN + Gln<br />
**[[3vp0]] – hGLN + Gln<br />
-
**[[3uo9]], [[3voz]], [[3vp2]], [[3vp3]], [[3vp4]], [[4o7d]] - hGLN + inhibitor<br />
+
**[[3uo9]], [[3voz]], [[3vp2]], [[3vp3]], [[3vp4]], [[4o7d]], [[5fi2]], [[5fi6]], [[5fi7]], [[5hl1]], [[5i94]], [[5jyo]], [[5jyp]] - hGLN + inhibitor<br />
**[[3iha]], [[3ihb]], [[3age]] - MlGLN + Glu<br />
**[[3iha]], [[3ihb]], [[3age]] - MlGLN + Glu<br />
**[[3ss5]] – mGLN + Glu<br />
**[[3ss5]] – mGLN + Glu<br />

Revision as of 09:03, 29 May 2017

Human glutaminase tetramer complex with glutamate 3unw

Drag the structure with the mouse to rotate

3D structures of glutaminase

Updated on 29-May-2017

References

  1. Curthoys NP. Role of mitochondrial glutaminase in rat renal glutamine metabolism. J Nutr. 2001 Sep;131(9 Suppl):2491S-5S; discussion 2496S-7S. PMID:11533299
  2. Steckel J, Roberts J, Philips FS, Chou TC. Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase. Biochem Pharmacol. 1983 Mar 15;32(6):971-7. PMID:6838661
  3. Erickson JW, Cerione RA. Glutaminase: a hot spot for regulation of cancer cell metabolism? Oncotarget. 2010 Dec;1(8):734-40. PMID:21234284 doi:http://dx.doi.org/10.18632/oncotarget.208
  4. Curthoys NP, Watford M. Regulation of glutaminase activity and glutamine metabolism. Annu Rev Nutr. 1995;15:133-59. PMID:8527215 doi:http://dx.doi.org/10.1146/annurev.nu.15.070195.001025
  5. Delabarre B, Gross S, Fang C, Gao Y, Jha A, Jiang F, Song J J, Wei W, Hurov JB. Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor. Biochemistry. 2011 Nov 18. PMID:22049910 doi:10.1021/bi201613d

Created with the participation of Lindsey Butler.

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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