Gramicidin

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		+	== References ==
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Revision as of 08:45, 16 March 2016

spinqualitylabelsall models Gramicidin D dimer with formyl-valine, formyl-isoleucine complex with PEG 1500 and ethanolamine , 2xdc Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Contents 1 Function 2 Relevance 3 3D Structures of Gramicidin 4 References

Function

Gramicidin (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria Bacillus brevis^[1].

• GCDN S is an antibiotic cyclic polypeptide.
  
• GCDN D is a mixture of GCDN A, B, C.
  

See theoretical model of Gramicidin Channel in Lipid Bilayer.

Relevance

GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive^[2].

3D Structures of Gramicidin

Updated on 16-March-2016

References

1. ↑ Urry DW, Goodall MC, Glickson JD, Mayers DF. The gramicidin A transmembrane channel: characteristics of head-to-head dimerized (L,D) helices. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1907-11. PMID:5288776
2. ↑ Kondejewski LH, Farmer SW, Wishart DS, Hancock RE, Hodges RS. Gramicidin S is active against both gram-positive and gram-negative bacteria. Int J Pept Protein Res. 1996 Jun;47(6):460-6. PMID:8836773