Gramicidin
From Proteopedia
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| + | <StructureSection load='2xds' size='350' side='right' caption='Gramicidin D dimer with formyl-valine, formyl-isoleucine complex with PEG 1500 and ethanolamine (PDB entry [[2xds]])' scene=''> | ||
== Function == | == Function == | ||
[[Gramicidin]] (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria ''Bacillus brevis''<ref>PMID:5288776</ref>.<br /> | [[Gramicidin]] (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria ''Bacillus brevis''<ref>PMID:5288776</ref>.<br /> | ||
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==Relevance == | ==Relevance == | ||
GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive<ref>PMID:8836773</ref>. | GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive<ref>PMID:8836773</ref>. | ||
| + | </StructureSection> | ||
== 3D Structures of Gramicidin == | == 3D Structures of Gramicidin == | ||
Revision as of 08:48, 16 March 2016
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3D Structures of Gramicidin
Updated on 16-March-2016
References
- ↑ Urry DW, Goodall MC, Glickson JD, Mayers DF. The gramicidin A transmembrane channel: characteristics of head-to-head dimerized (L,D) helices. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1907-11. PMID:5288776
- ↑ Kondejewski LH, Farmer SW, Wishart DS, Hancock RE, Hodges RS. Gramicidin S is active against both gram-positive and gram-negative bacteria. Int J Pept Protein Res. 1996 Jun;47(6):460-6. PMID:8836773
