This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Granzyme

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br />
'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br />
-
*'''Granzyme A and K''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br />
+
*'''Granzyme A''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br />
-
*'''Granzyme B and C''' induces cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br />
+
*'''Granzyme B and C''' inducesscytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br />
*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br />
*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br />
 +
*'''Granzyme K''' functions in a similar way to granzyme A <ref>PMID:19059912</ref>.<br />
*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br />
*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br />
</StructureSection>
</StructureSection>

Revision as of 09:39, 16 March 2016

Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry 1fq3)

Drag the structure with the mouse to rotate

3D structures of granzyme

Updated on 16-March-2016

References

  1. ↑ Bots M, Medema JP. Granzymes at a glance. J Cell Sci. 2006 Dec 15;119(Pt 24):5011-4. PMID:17158907 doi:http://dx.doi.org/10.1242/jcs.03239
  2. ↑ Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x. PMID:20536557 doi:http://dx.doi.org/10.1111/j.0105-2896.2010.00902.x
  3. ↑ Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunol Rev. 2003 Jun;193:31-8. PMID:12752668
  4. ↑ Waterhouse NJ, Trapani JA. H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol. 2007 Sep;28(9):373-5. Epub 2007 Sep 4. PMID:17766182 doi:http://dx.doi.org/10.1016/j.it.2007.08.001
  5. ↑ Bovenschen N, Quadir R, van den Berg AL, Brenkman AB, Vandenberghe I, Devreese B, Joore J, Kummer JA. Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. J Biol Chem. 2009 Feb 6;284(6):3504-12. doi: 10.1074/jbc.M806716200. Epub 2008, Dec 5. PMID:19059912 doi:http://dx.doi.org/10.1074/jbc.M806716200
  6. ↑ de Poot SA, Bovenschen N. Granzyme M: behind enemy lines. Cell Death Differ. 2014 Mar;21(3):359-68. doi: 10.1038/cdd.2013.189. Epub 2014, Jan 10. PMID:24413154 doi:http://dx.doi.org/10.1038/cdd.2013.189

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Granzyme"
Personal tools