1gxr
From Proteopedia
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'''WD40 REGION OF HUMAN GROUCHO/TLE1''' | '''WD40 REGION OF HUMAN GROUCHO/TLE1''' | ||
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[[Category: Pickles, L M.]] | [[Category: Pickles, L M.]] | ||
[[Category: Roe, S M.]] | [[Category: Roe, S M.]] | ||
| - | [[Category: | + | [[Category: Transcription repressor]] |
| - | [[Category: | + | [[Category: Wd repeat]] |
| - | [[Category: | + | [[Category: Wd40]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:09:16 2008'' | |
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Revision as of 15:09, 2 May 2008
WD40 REGION OF HUMAN GROUCHO/TLE1
Overview
Groucho (Gro)/TLE proteins are transcriptional corepressors that lack inherent DNA binding but interact with DNA-bound transcription factors and histones, and recruit histone deacetylases. Groucho-mediated repression is essential in embryonic development and involved in regulation of Wnt signaling in adult tissue. We have determined the 1.6 A crystal structure of a C-terminal fragment of human Groucho/TLE1, comprising part of the Ser/Pro-rich region and a seven-bladed beta propeller WD40 repeat domain, implicated in protein-protein interactions. The structure confirms the relationship to the yeast Tup1 corepressor, but reveals important structural differences specific to the metazoan system. Analysis of missense mutations in the C. elegans Groucho homolog UNC-37 identifies sites of interaction with repression effectors, and suggests an induced fit binding site for eh1 domains of Engrailed-type transcription factors.
About this Structure
1GXR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor., Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH, Structure. 2002 Jun;10(6):751-61. PMID:12057191 Page seeded by OCA on Fri May 2 18:09:16 2008
