GTP-binding protein

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<StructureSection load='3ieu' size='350' side='right' scene='' caption='E. coli small GTPase ERA complex with GDP (stick model), TRIS and sulfate (PDB code [[3ieu]])'>
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<StructureSection load='3cbq' size='350' side='right' scene='' caption='Human GTP-binding protein REM 2 complex with GDP and Mg+2 ion (green) (PDB code [[3cbq]])'>
[[Image:2nzj.png|left|200px|thumb|Crystal Structure of GTP-binding protein Rem1 tetramer complex with nucleotide [[2nzj]]]]
[[Image:2nzj.png|left|200px|thumb|Crystal Structure of GTP-binding protein Rem1 tetramer complex with nucleotide [[2nzj]]]]
{{Clear}}
{{Clear}}
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'''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: '''heterotrimeric G proteins'''<ref>PMID:14762218</ref> and '''small GTPases'''<ref>PMID:11152757</ref>. Small GTPase is homologous to the α subunit of heterotrimeric G protein. See details on GTP-binding protein LepA in [[LepA]].
+
'''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: '''heterotrimeric G proteins'''<ref>PMID:14762218</ref> and '''small GTPases'''<ref>PMID:11152757</ref>. See details on GTP-binding protein LepA in [[LepA]].
<scene name='Template:GPCR3sn6/3sn6memrane/15'>An activated G protein-coupled receptor</scene> (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) ([[3sn6]]), resolution 3.2&Aring;. The boundaries of the membrane in which the GPCR sits are represented in light green.
<scene name='Template:GPCR3sn6/3sn6memrane/15'>An activated G protein-coupled receptor</scene> (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) ([[3sn6]]), resolution 3.2&Aring;. The boundaries of the membrane in which the GPCR sits are represented in light green.
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**[[2eki]] – hGBP TGS domain – NMR - human<br />
**[[2eki]] – hGBP TGS domain – NMR - human<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
-
**[[2qtf]] – SsHflx<br />
+
**[[2qtf]] – SsHflx<br />**[[1ega]] – EcERA – ''Escherichia coli''<br />
-
**[[1ega]] – EcERA – ''Escherichia coli''<br />
+
**[[2dyk]] – TtEngA N terminal – ''Thermus thermophilus'' - Cryo EM<br />
**[[2dyk]] – TtEngA N terminal – ''Thermus thermophilus'' - Cryo EM<br />
-
**[[3cb4]] - EcLepA<br />
+
**[[3cb4]] - EcLepA – ''Escherichia coli''<br />
-
**[[2ywe]] – AaLepA<br />
+
**[[2ywe]] – AaLepA – ''Aquifex aeolicus''<br />
**[[1sul]] – BsYsxC - ''Bacillus subtilis''<br />
**[[1sul]] – BsYsxC - ''Bacillus subtilis''<br />
**[[2dwq]] – TtYchF<br />
**[[2dwq]] – TtYchF<br />
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**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
-
**[[1ni3]] – YchF – ''Schizosaccharomyces pombe''
+
**[[1ni3]] – YchF – ''Schizosaccharomyces pombe''<br />
*GTP-binding protein complex with nucleotide
*GTP-binding protein complex with nucleotide
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**[[3cbq]] – hRem2 + GDP<br />
**[[3cbq]] – hRem2 + GDP<br />
**[[3q85]] – hRem2 G domain + GTP analog<br />
**[[3q85]] – hRem2 G domain + GTP analog<br />
-
**[[2cjw]], [[2ht6]], [[2g3y]] – hGem G domain + GDP<br />
 
**[[4aii]] - rRem2 G domain + GDP - rat<br />
**[[4aii]] - rRem2 G domain + GDP - rat<br />
**[[2ohf]] – hOla1 + AMP-PCP<br />
**[[2ohf]] – hOla1 + AMP-PCP<br />
-
**[[1xtq]] – hRheB + GDP<br />
 
-
**[[1xts]] - hRheB + GTP<br />
 
-
**[[1xtr]] - hRheB + GPPNHP<br />
 
-
**[[3sea]] - hRheB + GDP + GNP<br />
 
**[[1e0a]] – hGBP (mutant) + GIP<br />
**[[1e0a]] – hGBP (mutant) + GIP<br />
**[[2b8w]], [[2d4h]] – hGBP N terminal + GMP<br />
**[[2b8w]], [[2d4h]] – hGBP N terminal + GMP<br />
**[[2b92]] - hGBP N terminal + GDP<br />
**[[2b92]] - hGBP N terminal + GDP<br />
**[[2bc9]] - hGBP N terminal + GPPNHP<br />
**[[2bc9]] - hGBP N terminal + GPPNHP<br />
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**[[4o25]] – mRheB + GTP - mouse<br />
 
-
**[[4o2l]] - mRheB (mutant) + GTP <br />
 
-
**[[4o2r]] - mRheB (mutant) + GDP <br />
 
**[[1yr7]], [[1yr8]] – PaGBP + GTP<br />
**[[1yr7]], [[1yr8]] – PaGBP + GTP<br />
**[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br />
**[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br />
**[[3kxi]], [[2qth]] – SsHflx + GDP<br />
**[[3kxi]], [[2qth]] – SsHflx + GDP<br />
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**[[3ieu]] – EcERA + GDP <br />
 
-
**[[3iev]] – AaERA + RNA + Mg-GNP – ''Aquifex aeolicus''<br />
 
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**[[1x1l]] – TtERA + RNA – Cryo EM<br />
 
**[[2ywf]] – AaLepA + GMP-PNP<br />
**[[2ywf]] – AaLepA + GMP-PNP<br />
**[[2ywg]] - AaLepA + GTP<br />
**[[2ywg]] - AaLepA + GTP<br />
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*GTP-binding protein complex with protein
*GTP-binding protein complex with protein
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**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
 
**[[3deg]] – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM<br />
**[[3deg]] – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM<br />
**[[3cue]] – yPt1 + transport protein subunits<br />
**[[3cue]] – yPt1 + transport protein subunits<br />
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**[[1m2o]] – ySar1 + protein transport protein sec23<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
**[[3syn]] – BsFlhf + ATP-binding protein<br />
**[[3syn]] – BsFlhf + ATP-binding protein<br />
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**[[3t5g]] – hRheB + GMP-PDE δ<br />
 
*GTP-binding protein 3 (Atlastin-1)
*GTP-binding protein 3 (Atlastin-1)
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**[[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated [[G protein-coupled receptor]] in a complex with its G protein.'''
**[[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated [[G protein-coupled receptor]] in a complex with its G protein.'''
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*'''Ras-related GTP-binding protein'''
+
*'''Ras-related small GTP-binding protein'''
**[[3llu]] – hC nucleotide-binding domain<br />
**[[3llu]] – hC nucleotide-binding domain<br />
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*Ras-related GTP-binding protein complex with nucleotide
+
*Ras-related small GTP-binding protein complex with nucleotide
**[[2l0x]] – rRheb + GDP <br />
**[[2l0x]] – rRheb + GDP <br />
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**[[1g17]] - ySec4 + GIP<br />
**[[1g17]] - ySec4 + GIP<br />
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*Ras-related GTP-binding protein complex with protein
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*Ras-related small GTP-binding protein complex with protein
**[[3kuc]] – hRap-1A + proto oncogene Ser/Thr protein kinase<br />
**[[3kuc]] – hRap-1A + proto oncogene Ser/Thr protein kinase<br />
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**[[3zys]] – hMx1 + dynamin-1<br />
**[[3zys]] – hMx1 + dynamin-1<br />
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*'''Rho-related GTP-binding protein'''
+
*'''Rho-related small GTP-binding protein'''
**[[2j1l]] – hRhoD
**[[2j1l]] – hRhoD
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*Rho-related GTP-binding protein complex with nucleotide
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*Rho-related small GTP-binding protein complex with nucleotide
**[[2cls]] – hRho6 + GTP<br />
**[[2cls]] – hRho6 + GTP<br />
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**[[2qrz]] - hCdc42 + GCP<br />
**[[2qrz]] - hCdc42 + GCP<br />
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*Rho-related GTP-binding protein complex with protein
+
*Rho-related small GTP-binding protein complex with protein
**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
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**[[2j0v]] – AtArac7 (mutant)<br />
**[[2j0v]] – AtArac7 (mutant)<br />
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*'''Rab-related GTP-binding protein'''
+
*'''Rab-related small GTP-binding protein'''
**[[2ys8]] – hRabJ DNAJ domain – NMR<br />
**[[2ys8]] – hRabJ DNAJ domain – NMR<br />
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*'''Small GTP-binding protein'''
*'''Small GTP-binding protein'''
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**[[2rhd]] – GBP – ''Cryptosporidium parvum''<br />
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**[[2rhd]] – Rab-1a – ''Cryptosporidium parvum''<br />
**[[1yzq]] - hRab-6 + GNP<br />
**[[1yzq]] - hRab-6 + GNP<br />
**[[3qq5]] – GBP – ''Thermotoga neapolitana''<br />
**[[3qq5]] – GBP – ''Thermotoga neapolitana''<br />
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*'''GTP-binding protein Ran'''
+
*'''Small GTP-binding protein ERA'''
 +
 
 +
**[[1ega]] – EcERA <br />
 +
**[[3ieu]] – EcERA + GDP <br />
 +
**[[3iev]] – AaERA + RNA + Mg-GNP <br />
 +
**[[1x1l]] – TtERA + RNA – Cryo EM<br />
 +
**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
 +
 
 +
*'''Small GTP-binding protein Rheb'''
 +
 
 +
**[[1xtq]] – hRheb + GDP<br />
 +
**[[1xts]] - hRheb + GTP<br />
 +
**[[1xtr]] - hRheb + GPPNHP<br />
 +
**[[3sea]] - hRheb + GDP + GNP<br />
 +
**[[4o25]] – mRheb + GTP - mouse<br />
 +
**[[4o2l]] - mRheb (mutant) + GTP <br />
 +
**[[4o2r]] - mRheb (mutant) + GDP <br />
 +
**[[3t5g]] – hRheB + GMP-PDE δ<br />
 +
 
 +
*'''Small GTP-binding protein Gem'''
 +
 
 +
**[[2cjw]], [[2ht6]], [[2g3y]] – hGem G domain + GDP<br />
 +
 
 +
*'''Small GTP-binding protein Ran'''
**[[2mmc]], [[2mmg]] – hRan <br />
**[[2mmc]], [[2mmg]] – hRan <br />

Revision as of 09:33, 17 March 2016

Human GTP-binding protein REM 2 complex with GDP and Mg+2 ion (green) (PDB code 3cbq)

Drag the structure with the mouse to rotate

3D Structures of GTP-binding protein

Updated on 17-March-2016

See Also

References

  1. ↑ Preininger AM, Hamm HE. G protein signaling: insights from new structures. Sci STKE. 2004 Jan 27;2004(218):re3. PMID:14762218 doi:http://dx.doi.org/10.1126/stke.2182004re3
  2. ↑ Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001 Jan;81(1):153-208. PMID:11152757
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