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| ===Monomers Per Turn=== | | ===Monomers Per Turn=== |
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| The ARC-1 model has 6.4 monomer chains per turn (56.0 degrees rotation between monomers). This is more chains/turn than some previous type IV pilus models. | | The ARC-1 model has 6.4 monomer chains per turn (56.0 degrees rotation between monomers). This is more chains/turn than some previous type IV pilus models. |
Revision as of 21:15, 4 March 2017
Monomers Per Turn
<iframe width="640" height="480" src="
https://sketchfab.com/models/f50ee70436064607940be49a356990e6/embed" frameborder="0" allowvr allowfullscreen mozallowfullscreen="true" webkitallowfullscreen="true" onmousewheel=""></iframe>
The ARC-1 model has 6.4 monomer chains per turn (56.0 degrees rotation between monomers). This is more chains/turn than some previous type IV pilus models.
To visualize chains/turn, we show (alpha carbon of Phe51). Then these chain-marking-atoms are , and the resulting helix is viewed from one end. When counting the chains/turn, bear in mind that the first and last (to complete one turn) count as 1/2 chain each.
Pilus
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Chains/Turn (Angle)
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Image
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Geobacter sulfurreducens (type IVa, 61 amino acids, theoretical model, 2016)[1]
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6.4 (56.0°)
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Pseudomonas aeruginosa (type IVa, 150 amino acids, fiber diffraction, 2004)[2]
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4.0 (90°)
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Vibrio cholerae (type IVb, 198 amino acids, cryo-EM, 2012)[3]
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3.7 (96.8°)
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Neisseria gonorrhoeae (type IVa, 165 amino acids, cryo-EM, 2006)[4]
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3.6 (100.8°)
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Notes & References
- ↑ Cite error: Invalid
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- ↑ Craig L, Pique ME, Tainer JA. Type IV pilus structure and bacterial pathogenicity. Nat Rev Microbiol. 2004 May;2(5):363-78. PMID:15100690 doi:http://dx.doi.org/10.1038/nrmicro885
- ↑ Li J, Egelman EH, Craig L. Structure of the Vibrio cholerae Type IVb Pilus and stability comparison with the Neisseria gonorrhoeae type IVa pilus. J Mol Biol. 2012 Apr 20;418(1-2):47-64. doi: 10.1016/j.jmb.2012.02.017. Epub 2012, Feb 21. PMID:22361030 doi:http://dx.doi.org/10.1016/j.jmb.2012.02.017
- ↑ Craig L, Volkmann N, Arvai AS, Pique ME, Yeager M, Egelman EH, Tainer JA. Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions. Mol Cell. 2006 Sep 1;23(5):651-62. PMID:16949362 doi:10.1016/j.molcel.2006.07.004