Hepatocyte growth factor activator

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
== Function ==
== Function ==
'''Hepatocyte growth factor activator''' (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury<ref>PMID:20402766</ref>.
'''Hepatocyte growth factor activator''' (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury<ref>PMID:20402766</ref>.
- 
-
== Disease ==
 
== Relevance ==
== Relevance ==
Line 9: Line 7:
== Structural highlights ==
== Structural highlights ==
-
 
+
HGFA substrate binding cleft resembles other trypsin-like serine proteases with inhibitors of the Kunitz type (α/β folds rich in Cys-Cys bonds) <ref>PMID:157134585</ref>.
</StructureSection>
</StructureSection>

Revision as of 10:46, 21 March 2016

Human hepatocyte growth factor activator (grey) complex with HGFA inhibitor type 1(wheat) and phosphate (PDB code 1yc0)

Drag the structure with the mouse to rotate

3D Structures of hepatocyte growth factor activator

Updated on 21-March-2016

1ybw – hHGFA protease domain – human
1yc0 – hHGFA protease domain + Kunitz-type protease inhibitor
2r0l, 2r0k, 2wub, 2wuc, 3k2u – hHGFA protease domain + antibody

References

  1. ↑ Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010 May;277(10):2208-14. doi: 10.1111/j.1742-4658.2010.07637.x. Epub, 2010 Apr 2. PMID:20402766 doi:http://dx.doi.org/10.1111/j.1742-4658.2010.07637.x
  2. ↑ Wu KL, Li YQ, Tabassum A, Lu WY, Aubert I, Wong CS. Loss of neuronal protein expression in mouse hippocampus after irradiation. J Neuropathol Exp Neurol. 2010 Mar;69(3):272-80. doi:, 10.1097/NEN.0b013e3181d1afe4. PMID:20142763 doi:http://dx.doi.org/10.1097/NEN.0b013e3181d1afe4
  3. ↑ . PMID:157134585

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Hepatocyte_growth_factor_activator"
Personal tools