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GTP-binding protein
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3ieu' size=' | + | <StructureSection load='3ieu' size='450' side='right' scene='46/463251/Cv/2' caption='E. coli small GTP-binding protein ERA complex with GDP and sulfate (PDB code [[3ieu]])'> |
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
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Mutations in heterotrimeric G protein α subunit were identified in endocrine tumors and in McCune-Albright syndrome<ref>PMID:11720871</ref>. | Mutations in heterotrimeric G protein α subunit were identified in endocrine tumors and in McCune-Albright syndrome<ref>PMID:11720871</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | ''E. coli'' small GTPase ERA binds GDP in a cavity formed by 3 highly conserved regions<ref>PMID:19706445</ref>. | + | ''E. coli'' small GTPase ERA binds GDP in a cavity formed by <scene name='46/463251/Cv/3'>3 highly conserved regions G1, G4, G5</scene><ref>PMID:19706445</ref>. <scene name='46/463251/Cv/6'>GDP binding site</scene>. Water molecules shown as red spheres. |
</StructureSection> | </StructureSection> | ||
__NOTOC__ | __NOTOC__ | ||
Revision as of 09:03, 22 March 2016
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3D Structures of GTP-binding protein
Updated on 22-March-2016
See Also
References
- ↑ Preininger AM, Hamm HE. G protein signaling: insights from new structures. Sci STKE. 2004 Jan 27;2004(218):re3. PMID:14762218 doi:http://dx.doi.org/10.1126/stke.2182004re3
- ↑ Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001 Jan;81(1):153-208. PMID:11152757
- ↑ Lania A, Mantovani G, Spada A. G protein mutations in endocrine diseases. Eur J Endocrinol. 2001 Nov;145(5):543-59. PMID:11720871
- ↑ Tu C, Zhou X, Tropea JE, Austin BP, Waugh DS, Court DL, Ji X. Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14843-8. Epub 2009 Aug 17. PMID:19706445
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