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Revision as of 12:42, 22 March 2016

Human Lysophosphatodic Acid Receptor 1

Figure 1: Chemical Structure of LPA

spinqualitylabelsall models LPA Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Lysophosphatodic Acid 2 Structure 2.1 Comparison of S1P and LPA 3 Function 4 Relevance 4.1 Clinical Testing Lysophosphatodic Acid Structure Comparison of S1P and LPA Lysophosphatidic Acid Receptors (LPA) are part of a larger family known as lysophospholipid receptor family (EDG family). Within this family there is a structure called S1P1. Since only the structures for LPA1 and S1P1 are known in the EDG family, comparisons are made between the two structures. There is a difference in binding paths between these two receptors. The binding path in the LPA1 is located in the extracellular milieu. While in the S1P1 the ligands are able to have access to the membrane so that the binding can occur. Figure 2: Comparison of the binding pockets of LPA1 and S1P1 receptors There is a difference in the shape of the electron density from the binding pocket. In S1P1 the binding pocket has more of an oval shape. For the LPA1 receptor the binding pocket has a spherical shape. Since the binding pocket is more spherical it gives LPA1 the ability to be able to recognize a larger group of chemical species. In particular the ability to bind with acyl chains of varying lengths. Function Relevance Clinical Testing This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

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1. ↑ Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA. Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 2015 Jun 18;161(7):1633-43. doi: 10.1016/j.cell.2015.06.002. PMID:26091040 doi:http://dx.doi.org/10.1016/j.cell.2015.06.002
2. ↑ Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med. 2008 Jan;14(1):45-54. Epub 2007 Dec 9. PMID:18066075 doi:http://dx.doi.org/10.1038/nm1685