User:Kurt Corsbie/Sandbox 1
From Proteopedia
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===Class C GPCR=== | ===Class C GPCR=== | ||
<StructureSection load='4oo9' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='4oo9' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | + | ==Introduction== | |
| - | == | + | ===Biological Background=== |
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G protein-coupled receptors (GPCRs) can be broken up into four classes: A, B, C, and F. <ref name="GPCR">PMID:23407534</ref>. Metabotropic glutamate receptor 5 (mGLu<sub>5</sub>) is a Class C GPCR that couples with the G<sub>q</sub> pathway <ref name="Pinj">PMID:12782243</ref>. | G protein-coupled receptors (GPCRs) can be broken up into four classes: A, B, C, and F. <ref name="GPCR">PMID:23407534</ref>. Metabotropic glutamate receptor 5 (mGLu<sub>5</sub>) is a Class C GPCR that couples with the G<sub>q</sub> pathway <ref name="Pinj">PMID:12782243</ref>. | ||
| + | ===Importance=== | ||
| + | == Function == | ||
== Structure == | == Structure == | ||
Revision as of 13:45, 22 March 2016
Metabotropic Glutamate Receptor 5 mGlu5 Homo sapiens
Class C GPCR
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References
- ↑ Venkatakrishnan AJ, Deupi X, Lebon G, Tate CG, Schertler GF, Babu MM. Molecular signatures of G-protein-coupled receptors. Nature. 2013 Feb 14;494(7436):185-94. doi: 10.1038/nature11896. PMID:23407534 doi:http://dx.doi.org/10.1038/nature11896
- ↑ Pin JP, Galvez T, Prezeau L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol Ther. 2003 Jun;98(3):325-54. PMID:12782243
