Sandbox Reserved 1167

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== Background ==
== Background ==
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The human glucagon receptor is one of 15 secretin-like, or Class B, members of G-protein-coupled receptors (GCPRs).
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During times of fasting (or low blood sugar) the pancreas dispatches glucagon to activate the GCPR in the liver, which causes the release of glucose into the blood. Because of this, it is being looked as a potential drug target for Type 2 diabetes.
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Secretin-like GPCRs contains both a 7tm domain (blue) and a globular N-terminus ECD (magenta)
<scene name='72/721538/7tm_labeled_helicies/3'>Labeled Helices of 7tm </scene>
<scene name='72/721538/7tm_labeled_helicies/3'>Labeled Helices of 7tm </scene>

Revision as of 12:15, 29 March 2016

This Sandbox is Reserved from Jan 11 through August 12, 2016 for use in the course CH462 Central Metabolism taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1160 through Sandbox Reserved 1184.
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  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, Carragher B, Yang H, Wang MW, Stevens RC, Jiang H. Conformational states of the full-length glucagon receptor. Nat Commun. 2015 Jul 31;6:7859. doi: 10.1038/ncomms8859. PMID:26227798 doi:http://dx.doi.org/10.1038/ncomms8859
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