1gzt

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[[Image:1gzt.gif|left|200px]]
[[Image:1gzt.gif|left|200px]]
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{{Structure
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|PDB= 1gzt |SIZE=350|CAPTION= <scene name='initialview01'>1gzt</scene>, resolution 1.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1gzt", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=FUA:Ca+Binding+Site+For+Chain+D'>FUA</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1gzt| PDB=1gzt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzt OCA], [http://www.ebi.ac.uk/pdbsum/1gzt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gzt RCSB]</span>
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}}
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'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''
'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''
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[[Category: Imberty, A.]]
[[Category: Imberty, A.]]
[[Category: Mitchell, E.]]
[[Category: Mitchell, E.]]
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[[Category: fucose]]
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[[Category: Fucose]]
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[[Category: lectin]]
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[[Category: Lectin]]
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[[Category: sugar-binding protein]]
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[[Category: Sugar-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:13:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:45 2008''
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Revision as of 15:13, 2 May 2008

Image:1gzt.gif

Template:STRUCTURE 1gzt

PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE


Overview

Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.

About this Structure

1GZT is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289 Page seeded by OCA on Fri May 2 18:13:50 2008

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