Histone methyltransferase
From Proteopedia
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| - | + | <StructureSection load='1o9s' size='350' side='right' caption='Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine (PDB entry [[2pm4]])' scene=''> | |
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== Function == | == Function == | ||
'''Histone methyltransferase''' (HMT) are '''histone-lysine N-methyltransferase''' (KHMT) and '''histone-arginine N-methyltransferase''' (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones<ref>PMID:15248813</ref>. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain. | '''Histone methyltransferase''' (HMT) are '''histone-lysine N-methyltransferase''' (KHMT) and '''histone-arginine N-methyltransferase''' (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones<ref>PMID:15248813</ref>. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain. | ||
| + | == Relevance == | ||
| + | Inhibitors of the histone-lysine N-methyltransferase SMYD2 which represses the tumor-suppressing activities of p53 are studied as cancer therapy drugs. | ||
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| + | == Disease == | ||
| + | Aberrant HMT plays a role in cancer, intellectual disability syndromes and regulation of tissue aging<ref>PMID:22473383</ref>. | ||
== 3D Structures of histone methyltransferase == | == 3D Structures of histone methyltransferase == | ||
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**[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br /> | **[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br /> | ||
**[[2w5y]] – hKHMT Hrx methyltransferase domain + SAH <br /> | **[[2w5y]] – hKHMT Hrx methyltransferase domain + SAH <br /> | ||
| - | **[[3lqi]], [[3lqj]] - hKHMT Mll Phd bromodomain + H3 peptide<br /> | ||
**[[3f2k]] – hKHMT Setmar SET domain + LYFA peptide<br /> | **[[3f2k]] – hKHMT Setmar SET domain + LYFA peptide<br /> | ||
**[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br /> | **[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br /> | ||
Revision as of 09:29, 24 March 2016
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