Histone methyltransferase

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== Relevance ==
== Relevance ==
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Inhibitors of the histone-lysine N-methyltransferase SMYD2 which represses the tumor-suppressing activities of p53 are studied as cancer therapy drug<ref>PMID:21782458</ref>.s.
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Inhibitors of the histone-lysine N-methyltransferase SMYD2 which represses the tumor-suppressing activities of p53 are studied as cancer therapy drugs<ref>PMID:21782458</ref>.
== Disease ==
== Disease ==
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*Histone-lysine N-methyltransferase binary complexes
*Histone-lysine N-methyltransferase binary complexes
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**[[2kkf]] – hKHMT Hrx CxxC domain +_DNA – NMR<br />
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**[[2kkf]] – hKHMT Hrx CxxC domain + DNA – NMR<br />
**[[4nw3]] – hKHMT Mll CxxC domain + DNA <br />
**[[4nw3]] – hKHMT Mll CxxC domain + DNA <br />
**[[4pzi]] – hKHMT CxxC domain + DNA <br />
**[[4pzi]] – hKHMT CxxC domain + DNA <br />
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**[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain +_DNA <br />
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**[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + DNA <br />
**[[3qow]] – hKHMT + SAM <br />
**[[3qow]] – hKHMT + SAM <br />
**[[4fmu]] – hKHMT SETD2 + inhibitor <br />
**[[4fmu]] – hKHMT SETD2 + inhibitor <br />

Revision as of 09:40, 24 March 2016

Human histone-lysine N-methyltrasferase (grey, green) complex with methylated lysine histone H3 peptide (rust, aqua) and S-adenosyl homocysteine (SAH) (PDB entry 1o9s)

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3D Structures of histone methyltransferase

Updated on 24-March-2016

References

  1. ↑ Trievel RC. Structure and function of histone methyltransferases. Crit Rev Eukaryot Gene Expr. 2004;14(3):147-69. PMID:15248813
  2. ↑ Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N. Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure. 2011 Jul 20. PMID:21782458 doi:10.1016/j.str.2011.06.011
  3. ↑ Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012 Apr 3;13(5):343-57. doi: 10.1038/nrg3173. PMID:22473383 doi:http://dx.doi.org/10.1038/nrg3173
  4. ↑ Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature. 2003 Feb 6;421(6923):652-6. Epub 2003 Jan 22. PMID:12540855 doi:10.1038/nature01378

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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