Sandbox Reserved 429
From Proteopedia
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The goal of a chemist is to develop a way to break this cell wall, thus destroying the bacteria. To achieve this, the penicillin is introduced to the bacteria and then reacts with PBPs (using β-lactam ring), preventing it from forming a cell wall. However, many pathogenic bacteria have evolved a way to mutate themselves to be immune to various drugs that contain this β-lactam rings. What happens is that bacterium produces enzyme, called β-lactamase that cleaves the β-lactam ring on a penicillin and thus preventing it from reacting with PBPs. To solve this problem, the new drug, called, lactivicin was developed that contains gamma-lactone rings and cycloserine as substitutions to β-lactam. So far, it has proved to be an efficient antibiotic. It successfully binds to PBPs and prevents cell wall from forming. | The goal of a chemist is to develop a way to break this cell wall, thus destroying the bacteria. To achieve this, the penicillin is introduced to the bacteria and then reacts with PBPs (using β-lactam ring), preventing it from forming a cell wall. However, many pathogenic bacteria have evolved a way to mutate themselves to be immune to various drugs that contain this β-lactam rings. What happens is that bacterium produces enzyme, called β-lactamase that cleaves the β-lactam ring on a penicillin and thus preventing it from reacting with PBPs. To solve this problem, the new drug, called, lactivicin was developed that contains gamma-lactone rings and cycloserine as substitutions to β-lactam. So far, it has proved to be an efficient antibiotic. It successfully binds to PBPs and prevents cell wall from forming. | ||
Recently, an analog of lactivicin, phenoxylactivicin (PLTV) was developed and is discussed in this article. | Recently, an analog of lactivicin, phenoxylactivicin (PLTV) was developed and is discussed in this article. | ||
| - | The complex of the PBP with <scene name='48/483886/ | + | The complex of the PBP with <scene name='48/483886/Pltv/1'>phenoxylactivicin</scene> is shown on the picture. |
Picture on the left is displayed as N-terminus to C-termiunus Rainbow for PBP complex. The coloring goes as shown on the sample: | Picture on the left is displayed as N-terminus to C-termiunus Rainbow for PBP complex. The coloring goes as shown on the sample: | ||
<blockquote> | <blockquote> | ||
Revision as of 16:52, 24 March 2016
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Penicillin binding protein/lactivicin (inhibitor) (2jch)[1]
by Tyler Carpenter, Samuel Pierce, Hyunjoon Choi, Anton El Khoury and Tiankai Zhang
Student Projects for UMass Chemistry 423 Spring 2016
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