1h05

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[[Image:1h05.gif|left|200px]]
[[Image:1h05.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1h05 |SIZE=350|CAPTION= <scene name='initialview01'>1h05</scene>, resolution 1.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1h05", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=SO1:So4+Binding+Site+For+Chain+A'>SO1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1h05| PDB=1h05 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h05 OCA], [http://www.ebi.ac.uk/pdbsum/1h05 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h05 RCSB]</span>
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}}
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'''3-DEHYDROQUINATE DEHYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH SULPHATE'''
'''3-DEHYDROQUINATE DEHYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH SULPHATE'''
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[[Category: Lapthorn, A J.]]
[[Category: Lapthorn, A J.]]
[[Category: Roszak, A W.]]
[[Category: Roszak, A W.]]
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[[Category: alpha/beta protein]]
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[[Category: Alpha/beta protein]]
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[[Category: aromatic amino acid biosynthesis]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: dehydratase]]
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[[Category: Dehydratase]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: shikimate pathway]]
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[[Category: Shikimate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:14:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:59 2008''
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Revision as of 15:14, 2 May 2008

Image:1h05.gif

Template:STRUCTURE 1h05

3-DEHYDROQUINATE DEHYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH SULPHATE


Overview

The interactions between the polyanionic ligands phosphate and sulphate and the type II dehydroquinases from Streptomyces coelicolor and Mycobacterium tuberculosis have been characterised using a combination of structural and kinetic methods. From both approaches, it is clear that interactions are more complex in the case of the latter enzyme. The data provide new insights into the differences between the two enzymes in terms of substrate recognition and catalytic efficiency and may also explain the relative potencies of rationally designed inhibitors. An improved route to the synthesis of the substrate 3-dehydroquinic acid (dehydroquinate) is described.

About this Structure

1H05 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions., Evans LD, Roszak AW, Noble LJ, Robinson DA, Chalk PA, Matthews JL, Coggins JR, Price NC, Lapthorn AJ, FEBS Lett. 2002 Oct 23;530(1-3):24-30. PMID:12387860 Page seeded by OCA on Fri May 2 18:14:46 2008

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