User:Dean Williams/Sandbox 1180

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Introduction

Signaling is via coupling to heterotrimeric G-proteins

Activates adenylate cyclase

Upregulates intracellular cAMP

Upregulates inositol phosphate

Increases intracellular Ca2+

Disease

Diabetes Mellitus

Biological Function of Glucagon

Biochemical Significance

Kinetics

Ligand Binding

Sequence Conservation and Homology

Conformational Change

Structural highlights

Crucial Structural Interactions

Peptide Sequence

Active Binding Sites

Relevance

Class B in Comparison to Class A

Figure Legend

Structural Similarities

Sequential Similarities

Current Drug Targets

Future Direction

Drug Development

Possible Structures for Agonists

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