User:Dean Williams/Sandbox 1180
From Proteopedia
(Difference between revisions)
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Increases intracellular Ca2+ | Increases intracellular Ca2+ | ||
| + | ==Comparisons to other G proteins== | ||
| + | |||
| + | ===Structural similarities=== | ||
| + | Done | ||
| + | |||
| + | ===Sequential similarities=== | ||
| + | Snake Chain | ||
| + | |||
| + | |||
| + | ==Functions of Glucagon receptor== | ||
| + | |||
| + | ===Peptide binding and selectivity=== | ||
| + | from presentation | ||
| + | |||
| + | ===Conformational changes=== | ||
| + | |||
| + | ===Signaling pathway involvement=== | ||
| + | Textbook Reference | ||
| + | |||
| + | ==Kinetics== | ||
| + | |||
| + | |||
| + | ==Ligand specifics== | ||
| + | |||
| + | ===Peptide sequence=== | ||
| + | |||
| + | ===Active binding domains/sites=== | ||
| + | Dean can add images | ||
| + | |||
| + | ===Biological function of glucagon=== | ||
| + | |||
| + | ===Signaling pathways=== | ||
| + | |||
| + | |||
| + | ==Clinical relevance== | ||
| + | |||
| + | ===Future research direction=== | ||
| + | |||
| + | ===Current drug targets=== | ||
| + | See “Landmark studies on the glucagon subfamily of GPCRs: from small molecule | ||
| + | modulators to a crystal structure” good clinical references and small molecule | ||
| + | target tables | ||
| + | |||
| + | ===Possible structural considerations for agonists=== | ||
| + | (our distance measurements and shape analysis images) | ||
| + | Also see Landmark studies on the glucagon subfamily of GPCRs: from small | ||
| + | molecule modulators to a crystal structure | ||
| - | == Disease == | ||
| - | === Diabetes Mellitus === | ||
| - | === Biological Function of Glucagon === | ||
| - | == Biochemical Significance == | ||
| - | === Kinetics === | ||
| - | === Ligand Binding === | ||
| - | === Sequence Conservation and Homology === | ||
| - | === Conformational Change === | ||
| - | == Structural highlights == | ||
| - | === Crucial Structural Interactions === | ||
| - | === Peptide Sequence === | ||
| - | === Active Binding Sites === | ||
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==== Sequential Similarities ==== | ==== Sequential Similarities ==== | ||
=== Current Drug Targets === | === Current Drug Targets === | ||
| - | |||
| - | == Future Direction == | ||
| - | === Drug Development === | ||
| - | === Possible Structures for Agonists === | ||
Revision as of 17:45, 25 March 2016
Structure of Class B Human Glucagon G-Protein Coupled Receptors
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
