This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1h0h
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1h0h.gif|left|200px]] | [[Image:1h0h.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1h0h", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1h0h| PDB=1h0h | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS''' | '''TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS''' | ||
| Line 26: | Line 23: | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Raaijmakers, H C.A.]] | [[Category: Raaijmakers, H C.A.]] | ||
| - | [[Category: | + | [[Category: Iron-sulphur cluster]] |
| - | [[Category: | + | [[Category: Mgd]] |
| - | [[Category: | + | [[Category: Molybdopterin]] |
| - | [[Category: | + | [[Category: Periplasmic]] |
| - | [[Category: | + | [[Category: Selenocysteine]] |
| - | [[Category: | + | [[Category: Tungsten selenium formate dehydrogenase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:15:20 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:15, 2 May 2008
TUNGSTEN CONTAINING FORMATE DEHYDROGENASE FROM DESULFOVIBRIO GIGAS
Overview
Desulfovibrio gigas formate dehydrogenase is the first representative of a tungsten-containing enzyme from a mesophile that has been structurally characterized. It is a heterodimer of 110 and 24 kDa subunits. The large subunit, homologous to E. coli FDH-H and to D. desulfuricans nitrate reductase, harbors the W site and one [4Fe-4S] center. No small subunit ortholog containing three [4Fe-4S] clusters has been reported. The structural homology with E. coli FDH-H shows that the essential residues (SeCys158, His159, and Arg407) at the active site are conserved. The active site is accessible via a positively charged tunnel, while product release may be facilitated, for H(+) by buried waters and protonable amino acids and for CO(2) through a hydrophobic channel.
About this Structure
1H0H is a Protein complex structure of sequences from Desulfovibrio gigas. Full crystallographic information is available from OCA.
Reference
Gene sequence and the 1.8 A crystal structure of the tungsten-containing formate dehydrogenase from Desulfovibrio gigas., Raaijmakers H, Macieira S, Dias JM, Teixeira S, Bursakov S, Huber R, Moura JJ, Moura I, Romao MJ, Structure. 2002 Sep;10(9):1261-72. PMID:12220497 Page seeded by OCA on Fri May 2 18:15:20 2008
