1h1z

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[[Image:1h1z.jpg|left|200px]]
[[Image:1h1z.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1h1z |SIZE=350|CAPTION= <scene name='initialview01'>1h1z</scene>, resolution 3.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1h1z", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ZNA:So4+Binding+Site+For+Chain+B'>ZNA</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribulose-phosphate_3-epimerase Ribulose-phosphate 3-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.1 5.1.3.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1h1z| PDB=1h1z | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h1z OCA], [http://www.ebi.ac.uk/pdbsum/1h1z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h1z RCSB]</span>
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}}
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'''THE STRUCTURE OF THE CYTOSOLIC D-RIBULOSE-5-PHOSPHATE 3-EPIMERASE FROM RICE COMPLEXED WITH SULFATE AND ZINC'''
'''THE STRUCTURE OF THE CYTOSOLIC D-RIBULOSE-5-PHOSPHATE 3-EPIMERASE FROM RICE COMPLEXED WITH SULFATE AND ZINC'''
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[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
[[Category: 3-epimerase]]
[[Category: 3-epimerase]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: oxidative pentose phosphate pathway]]
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[[Category: Oxidative pentose phosphate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:19:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:55:59 2008''
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Revision as of 15:19, 2 May 2008

Image:1h1z.jpg

Template:STRUCTURE 1h1z

THE STRUCTURE OF THE CYTOSOLIC D-RIBULOSE-5-PHOSPHATE 3-EPIMERASE FROM RICE COMPLEXED WITH SULFATE AND ZINC


Overview

Cytosolic D-ribulose-5-phosphate 3-epimerase from rice was crystallized after EDTA treatment and structurally elucidated by X-ray diffraction to 1.9A resolution. A prominent Zn(2+) site at the active center was established in a soaking experiment. The structure was compared with that of the EDTA-treated crystalline enzyme from the chloroplasts of potato plant leaves showing some structural differences, in particular the "closed" state of a strongly conserved mobile loop covering the substrate at its putative binding site. The previous proposal for the active center was confirmed and the most likely substrate binding position and conformation was derived from the locations of the bound zinc and sulfate ions and of three water molecules. Assuming that the bound zinc ion is an integral part of the enzyme, a reaction mechanism involving a well-stabilized cis-enediolate intermediate is suggested.

About this Structure

1H1Z is a Single protein structure of sequence from Oryza sativa. Full crystallographic information is available from OCA.

Reference

Structure and catalytic mechanism of the cytosolic D-ribulose-5-phosphate 3-epimerase from rice., Jelakovic S, Kopriva S, Suss KH, Schulz GE, J Mol Biol. 2003 Feb 7;326(1):127-35. PMID:12547196 Page seeded by OCA on Fri May 2 18:19:01 2008

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