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Insulin receptor
From Proteopedia
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== Disease == | == Disease == | ||
IR is important for the regulation of glucose homeostasis and its malfunction can cause diabetics and cancer. IR is overexpressed in cancer<ref>PMID:18465356</ref>. | IR is important for the regulation of glucose homeostasis and its malfunction can cause diabetics and cancer. IR is overexpressed in cancer<ref>PMID:18465356</ref>. | ||
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| + | == Structural highlights == | ||
| + | TK domain of IR contains an activation loop and a catalytic loop and 3 phosphorylated tyrosine residues. The bound IR substrate 2 peptide tyrosine is the phosphorylated residue<ref>PMID:18278056</ref>. | ||
See also [[Insulin Receptor - kinase domain (hebrew)]]. | See also [[Insulin Receptor - kinase domain (hebrew)]]. | ||
Revision as of 08:58, 29 March 2016
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Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, R. Jeremy Johnson, Karsten Theis, Jaime Prilusky
