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Hepatocyte growth factor activator

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== Structural highlights ==
== Structural highlights ==
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HGFA substrate binding cleft resembles other trypsin-like serine proteases with inhibitors of the Kunitz type (α/β folds rich in Cys-Cys bonds) <ref>PMID:157134585</ref>.
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HGFA substrate binding cleft resembles other trypsin-like serine proteases with <scene name='70/706236/Cv/2'>inhibitors of the Kunitz type (α/β folds rich in Cys-Cys bonds)</scene> <ref>PMID:157134585</ref>.
</StructureSection>
</StructureSection>

Revision as of 11:47, 29 March 2016

Human hepatocyte growth factor activator (magenta) complex with HGFA inhibitor type 1 (green) and phosphate (PDB code 1yc0)

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3D Structures of hepatocyte growth factor activator

Updated on 29-March-2016

1ybw – hHGFA protease domain – human
1yc0 – hHGFA protease domain + Kunitz-type protease inhibitor
2r0l, 2r0k, 2wub, 2wuc, 3k2u – hHGFA protease domain + antibody

References

  1. ↑ Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010 May;277(10):2208-14. doi: 10.1111/j.1742-4658.2010.07637.x. Epub, 2010 Apr 2. PMID:20402766 doi:http://dx.doi.org/10.1111/j.1742-4658.2010.07637.x
  2. ↑ Wu KL, Li YQ, Tabassum A, Lu WY, Aubert I, Wong CS. Loss of neuronal protein expression in mouse hippocampus after irradiation. J Neuropathol Exp Neurol. 2010 Mar;69(3):272-80. doi:, 10.1097/NEN.0b013e3181d1afe4. PMID:20142763 doi:http://dx.doi.org/10.1097/NEN.0b013e3181d1afe4
  3. ↑ . PMID:157134585

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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