Sandbox Reserved 1167
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
== Background == | == Background == | ||
| - | The human glucagon receptor is one of 15 secretin-like, or Class B, members of G-protein-coupled receptors (GCPRs). | + | The human glucagon receptor is one of 15 secretin-like, or Class B, members of G-protein-coupled receptors (GCPRs). Like other GCPRs, it has a 7 trans-membrane helical domain (<scene name='72/721538/7tm_labeled_helicies/3'>Labeled Helices of 7tm </scene>) and a globular N-terminus extracellular domain (<scene name='72/721538/Ecd/2'>ECD</scene>). |
| - | During times of fasting (or low blood sugar) the pancreas dispatches glucagon to activate the GCPR in the liver, which causes the release of glucose into the blood. | + | During times of fasting (or low blood sugar) the pancreas dispatches glucagon to activate the GCPR in the liver, which causes the release of glucose into the blood. |
Secretin-like GPCRs contains both a 7tm domain (blue) and a globular N-terminus ECD (magenta) | Secretin-like GPCRs contains both a 7tm domain (blue) and a globular N-terminus ECD (magenta) | ||
| - | + | ||
<scene name='72/721538/7tm/2'>7tm</scene> | <scene name='72/721538/7tm/2'>7tm</scene> | ||
| - | The Extracellular Domain | + | The Extracellular Domain has a α-β-β structure which consists of two antiparallel β-sheets and an N-terminal α-helix<ref>PMID:26227798</ref>. |
== Function == | == Function == | ||
| Line 43: | Line 43: | ||
== Clinical Relevance == | == Clinical Relevance == | ||
| + | Because of this, it is being looked as a potential drug target for Type 2 diabetes. | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 12:38, 29 March 2016
| This Sandbox is Reserved from Jan 11 through August 12, 2016 for use in the course CH462 Central Metabolism taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1160 through Sandbox Reserved 1184. |
To get started:
More help: Help:Editing |
Your Heading Here (maybe something like 'Structure')
| |||||||||||
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, Carragher B, Yang H, Wang MW, Stevens RC, Jiang H. Conformational states of the full-length glucagon receptor. Nat Commun. 2015 Jul 31;6:7859. doi: 10.1038/ncomms8859. PMID:26227798 doi:http://dx.doi.org/10.1038/ncomms8859
