User:Dean Williams/Sandbox 1180

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Introduction

Signaling is via coupling to heterotrimeric G-proteins

Activates adenylate cyclase

Upregulates intracellular cAMP

Upregulates inositol phosphate

Increases intracellular Ca2+

Comparisons to other G proteins

Structural similarities

Similarities between Class A and

Sequential similarities

Snake Chain

Functions of Glucagon receptor

Peptide binding and selectivity

from presentation

Conformational changes

Signaling pathway involvement

Textbook Reference

Kinetics

Ligand specifics

Peptide sequence

Active binding domains/sites

Dean can add images

Biological function of glucagon

Signaling pathways

Clinical relevance

Future research direction

Current drug targets

See “Landmark studies on the glucagon subfamily of GPCRs: from small molecule

		modulators to a crystal structure” good clinical references and small molecule 

target tables

Possible structural considerations for agonists

(our distance measurements and shape analysis images) Also see Landmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structure

Relevance

Class B in Comparison to Class A

Figure Legend

Structural Similarities

Sequential Similarities

Current Drug Targets

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