1h3z

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[[Image:1h3z.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_1h3z| PDB=1h3z | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3z OCA], [http://www.ebi.ac.uk/pdbsum/1h3z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h3z RCSB]</span>
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'''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE'''
'''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE'''
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[[Category: Bycroft, M.]]
[[Category: Bycroft, M.]]
[[Category: Slater, L M.]]
[[Category: Slater, L M.]]
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[[Category: beta-barrel]]
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[[Category: Beta-barrel]]
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[[Category: chromatin]]
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[[Category: Chromatin]]
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[[Category: pwwp]]
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[[Category: Pwwp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:24:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:57:14 2008''
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Revision as of 15:24, 2 May 2008

Template:STRUCTURE 1h3z

SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE


Overview

The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.

About this Structure

1H3Z is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Structural variation in PWWP domains., Slater LM, Allen MD, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:12842472 Page seeded by OCA on Fri May 2 18:24:11 2008

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